Summary

Name CEBPB
Full Name CCAAT/enhancer-binding protein beta
Synonyms C/EBP beta, Liver activator protein, LAP, Liver-enriched inhibitory protein, LIP, Nuclear factor NF-IL6, Transcription factor 5, TCF-5 | TCF5
Primary ID P17676
Links - -
Type protein
Relations 66
Pathways Adipogenesis, Acute Myeloid Leukemia, miRNA in AML, FAP: In vitro induction of adipogenesis, FAP: Adipogenic transcriptional cascade, FAP: Glucocorticoids, FAP: IBMX/rosiglitazone, FAP: Notch, FAP: SHH, FAP: TGF beta, FAP: GCR-cAMP crosstalk, FLT3-ITD signaling, FAP: miRNA and adipogensis, Monocyte: IL10 transcriptional regulation, Pericyte: In vitro induction of adipogenesis
Function Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.472
Publications: 3 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png phosphorylation CEBPB 0.331
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.41
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.703
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.348
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CEBPB 0.472
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, Acute Myeloid Leukemia, FLT3-ITD signaling
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.652
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CEBPB 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, FLT3-ITD signaling
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.278
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.412
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Adipogenesis 0.7
Publications: 2 Organism: Mus Musculus,
Pathways:Adipogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TNFAIP6 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Differentiation 0.7
Publications: 1
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation CEBPB 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GFER 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF5 0.69
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SLC19A1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CREB1 (isoform 1) 0.584
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png binding CEBPB 0.576
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CEBPB 0.334
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png transcriptional regulation CEBPB 0.334
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPB 0.476
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL10 0.367
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CEBPB 0.537
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PCK2 0.337
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CEBPB 0.284
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CEBPB 0.303
Publications: 1
Pathways:Acute Myeloid Leukemia, miRNA in AML, FLT3-ITD signaling
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ADM 0.248
Publications: 1
+ up-regulates quantity img/direct-activation.png transcriptional regulation PPARG 0.719
Publications: 2 Organism: Mus Musculus
Pathways:Adipogenesis
+ down-regulates activity img/direct_inhibition.png binding, transcriptional regulation CEBPB 0.556
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation GDF15 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation, CEBPB 0.8
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CEBPB 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation S100A9 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPB 0.584
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, FLT3-ITD signaling
+ up-regulates activity img/indirect-activation.png Neurodegeneration 0.7
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png transcriptional regulation SREBF1 0.425
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding CEBPB 0.364
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png CEBPB 0.444
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CSRP1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SLC5A8 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CEBPB 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation STAR 0.378
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation C3 0.264
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation CEBPB 0.669
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCB1 0.458
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SFTPD 0.255
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination CEBPB 0.273
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CEBPB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CEBPB 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CEBPB 0.476
Publications: 2 Organism: Rattus Norvegicus, Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation GOT1 0.2
Publications: 1
+ down-regulates quantity img/direct_inhibition.png post transcriptional regulation CEBPB 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPB 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HSD11B1 0.291
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CEBPB 0.512
Publications: 1 Organism: Homo Sapiens