Summary

Name EIF6
Full Name Eukaryotic translation initiation factor 6
Synonyms eIF-6, B(2)GCN homolog, B4 integrin interactor, CAB, p27(BBP) | EIF3A, ITGB4BP
Primary ID P56537
Links - -
Type protein
Relations 6
Pathways Initiation of Translation
Function Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ PRKCA img/unknown.png phosphorylation EIF6 0.323
Publications: 1 Organism: Homo Sapiens
+ PRKCBdown-regulates activity img/direct_inhibition.png phosphorylation EIF6 0.311
Publications: 1 Organism: Homo Sapiens
+ SBDSup-regulates img/indirect-activation.png EIF6 0.532
Publications: 1 Organism: Homo Sapiens
+ EFL1up-regulates img/indirect-activation.png EIF6 0.2
Publications: 1 Organism: Homo Sapiens
+ EIF6up-regulates quantity img/direct-activation.png binding 60S cytosolic large ribosomal subunit 0.504
Publications: 1 Organism: Homo Sapiens
Pathways:Initiation of Translation
+ EIF6down-regulates activity img/direct_inhibition.png binding 60S cytosolic large ribosomal subunit 0.504
Publications: 1 Organism: Homo Sapiens
Pathways:Initiation of Translation