| + |
BACE1 | up-regulates activity 
cleavage
|
APP |
0.787 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261763 |
Asp616 |
EISEVKMdAEFRHDS |
Homo sapiens |
|
| pmid |
sentence |
| 10931940 |
Figure 6 Preferred BACE1 and BACE2 cleavage sites. (A) Sequence of APP indicating α- and β-cleavage sites, BACE1- and BACE2-cleavage sites, and the location of mutations analyzed here. APP numbering is that of the 770-aa isoform. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255480 |
|
|
|
|
| pmid |
sentence |
| 28923680 |
Beta-secretase 1 (BACE1) cleaves the type-I transmembrane protein APP to form the N-terminus of Aβ. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, |
| + |
USP8 | up-regulates quantity by stabilization
deubiquitination
|
BACE1 |
0.462 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259101 |
Lys501 |
ADDISLLk |
Homo sapiens |
H4 Neuroglioma Cell |
| pmid |
sentence |
| 27302062 |
Accordingly, we reported that BACE1 is ubiquitinated at lysine 501 and that lack of ubiquitination at lysine 501 produces BACE1 stabilization.Our findings demonstrate that USP8 plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK1D |
phosphorylation
|
BACE1 |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250797 |
Ser498 |
DDFADDIsLLK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11278841 |
Here, we report that BACE can be phosphorylated within its cytoplasmic domain at serine residue 498 by casein kinase 1. Phosphorylation exclusively occurs after full maturation of BACE by propeptide cleavage and complex N-glycosylation. | After reinternalization, BACE wild type as well as BACE S498D are efficiently retrieved from early endosomal compartments and further targeted to later endosomal compartments and/or the trans-Golgi network. In contrast, nonphosphorylatable BACE S498A is retained within early endosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK5/CDK5R1 | up-regulates activity
phosphorylation
|
BACE1 |
0.384 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276934 |
Thr252 |
YTGSLWYtPIRREWY |
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 26317805 |
First, we show that BACE1 is phosphorylated by the p25/Cdk5 complex at Thr252 and that this phosphorylation increases BACE1 activity. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
FBXO2 | down-regulates quantity by destabilization 
binding
|
BACE1 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271904 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 20854419 |
SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer’s disease amyloidosis and improves synaptic function. We report that the SCF(Fbx2) -E3 ligase is involved in the binding and ubiquitination of BACE1 via its Trp 280 residue of F-box-associated domain. we found that overexpression of Fbx2 in the primary cortical and hippocampal neurons derived from Tg2576 transgenic mice significantly promoted BACE1 degradation and reduced β-amyloid production. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
USP8 | up-regulates quantity
deubiquitination
|
BACE1 |
0.462 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266905 |
|
|
Homo sapiens |
H4 Neuroglioma Cell |
| pmid |
sentence |
| 27302062 |
Here, we report that RNAi-mediated depletion of USP8 reduced levels of both ectopically expressed and endogenous BACE1 in H4 human neuroglioma cells. Moreover, USP8 depletion increased BACE1 ubiquitination, promoted BACE1 accumulation in the early endosomes and late endosomes/lysosomes, and decreased levels of BACE1 in the recycling endosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
BACE1 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271903 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 20854419 |
SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer’s disease amyloidosis and improves synaptic function. We report that the SCF(Fbx2) -E3 ligase is involved in the binding and ubiquitination of BACE1 via its Trp 280 residue of F-box-associated domain. we found that overexpression of Fbx2 in the primary cortical and hippocampal neurons derived from Tg2576 transgenic mice significantly promoted BACE1 degradation and reduced β-amyloid production. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
BACE1
- 
- 