3.0
Summary
| Name |  USP8View Modifications |
| Full Name | Ubiquitin carboxyl-terminal hydrolase 8 |
| Synonyms | Deubiquitinating enzyme 8, Ubiquitin isopeptidase Y, hUBPy, Ubiquitin thioesterase 8, Ubiquitin-specific-processing protease 8 | KIAA0055, UBPY |
| Primary ID | P40818 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | USP8 | up-regulates quantity by stabilization 
deubiquitination
|
BACE1 | 0.462 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP8 | up-regulates quantity by stabilization
deubiquitination
|
EGFR | 0.7 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | USP8 | up-regulates quantity
deubiquitination
|
BACE1 | 0.462 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP8 | up-regulates quantity by stabilization
deubiquitination
|
RNF41 | 0.875 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP8 | up-regulates quantity
binding
|
STAM | 0.551 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF41 | down-regulates quantity by destabilization 
ubiquitination
|
USP8 | 0.875 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP8 | down-regulates quantity
destabilization
|
EGFR | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP8 | down-regulates quantity
destabilization
|
MET | 0.432 |
| Publications: | 1 | Organism: | Homo Sapiens | |