3.0
Summary
| Name |  MLF1
|
| Full Name | Myeloid leukemia factor 1 |
| Synonyms | Myelodysplasia-myeloid leukemia factor 1 |
| Primary ID | P58340 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. |
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