Summary

Name UBE2N
Full Name Ubiquitin-conjugating enzyme E2 N
Synonyms Bendless-like ubiquitin-conjugating enzyme, E2 ubiquitin-conjugating enzyme N, Ubc13, UbcH13, Ubiquitin carrier protein N, Ubiquitin-protein ligase N | BLU
Primary ID P61088
Links - -
Type protein
Relations 9
Pathways NF-KB Canonical
Function The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175, PubMed:31006531). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway.

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Relations

Regulator Mechanism target score ℹ
+ Ub:E1 (UBA1 substrate)up-regulates activity img/direct-activation.png ubiquitination UBE2N 0.85
Publications: 1 Organism: Homo Sapiens
+ RNF8up-regulates img/direct-activation.png binding UBE2N 0.74
Publications: 1 Organism: Homo Sapiens
+ TRAF2up-regulates activity img/direct-activation.png binding UBE2N 0.439
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , NF-KB Canonical
+ UBE2Nup-regulates activity img/direct-activation.png ubiquitination TRAF2 0.439
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , NF-KB Canonical
+ UBE2Nup-regulates img/direct-activation.png ubiquitination H2AX 0.2
Publications: 1 Organism: Homo Sapiens
+ OTUB1down-regulates img/direct_inhibition.png binding UBE2N 0.727
Publications: 1 Organism: Homo Sapiens
+ Ub:E1 (UBA6 substrate)up-regulates activity img/direct-activation.png ubiquitination UBE2N 0.753
Publications: 1 Organism: Homo Sapiens
+ UBE2Nup-regulates activity img/direct-activation.png binding UBE2V1 0.849
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , NF-KB Canonical
+ UBE2Nup-regulates activity img/direct-activation.png ubiquitination TRIM63 0.518
Publications: 1 Organism: In Vitro