Summary

Name UBE2V1
Full Name Ubiquitin-conjugating enzyme E2 variant 1
Synonyms UEV-1, CROC-1, TRAF6-regulated IKK activator 1 beta Uev1A | CROC1, UBE2V, UEV1
Primary ID Q13404
Links - -
Type protein
Relations 4
Pathways NF-KB Canonical
Function Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed:31006531). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway.

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Relations

Regulator Mechanism target score ℹ
+ UBE2V1up-regulates activity img/direct-activation.png binding TRAF6 0.687
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , NF-KB Canonical
+ Ub:E1 (UBA6 substrate)up-regulates activity img/direct-activation.png ubiquitination UBE2V1 0.442
Publications: 1 Organism: Homo Sapiens
+ Ub:E1 (UBA1 substrate)up-regulates activity img/direct-activation.png ubiquitination UBE2V1 0.563
Publications: 1 Organism: Homo Sapiens
+ UBE2Nup-regulates activity img/direct-activation.png binding UBE2V1 0.849
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , NF-KB Canonical