4.0
Summary
| Name |  PCBD1
|
| Full Name | Pterin-4-alpha-carbinolamine dehydratase |
| Synonyms | PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Dimerization cofactor of hepatocyte nuclear factor 1-alpha, DCoH, Dimerization cofactor of HNF1, Phenylalanine hydroxylase-stimulating protein, Pterin carbinolamine dehydratase, PCD | DCOH, PCBD |
| Primary ID | P61457 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PCBD1 | up-regulates activity 
binding
|
HNF1B | 0.581 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Renal Distal Tubule | |||
| + | PCBD1 | up-regulates quantity by expression 
transcriptional regulation
|
FXYD2 | 0.347 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Renal Distal Tubule | |||