Summary

Name DCAF7
Full Name DDB1- and CUL4-associated factor 7
Synonyms WD repeat-containing protein 68, WD repeat-containing protein An11 homolog | HAN11, WDR68
Primary ID P61962
Links - -
Type protein
Relations 3
Function Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Viewer

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding DYRK1B 0.757
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GLI1 0.266
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DYRK1A 0.738
Publications: 1 Organism: Chlorocebus Aethiops