| + |
DYRK1B | up-regulates 
phosphorylation
|
CDKN1B |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235805 |
Ser10 |
NVRVSNGsPSLERMD |
Mus musculus |
|
| pmid |
sentence |
| 15546868 |
Mirk phosphorylates p27 at ser-10, thus stabilizing p27 and blocking its nuclear export and degradation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
DYRK1B | up-regulates activity
phosphorylation
|
CDKN1A |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235635 |
Ser153 |
SMTDFYHsKRRLIFS |
Mus musculus |
|
| pmid |
sentence |
| 15851482 |
Mirk exerts its anti-apoptotic effects during muscle differentiation at least in part through effects on the cell cycle inhibitor and pro-survival molecule p21cip1. Overexpression and rna interference experiments demonstrated that mirk phosphorylates p21 within its nuclear localization domain at ser-153 causing a portion of the typically nuclear p21 to localize in the cytoplasm.Translocation to the cytoplasm enables p21 to block apoptosis through inhibitory interaction with pro-apoptotic molecules. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
DYRK1B | down-regulates 
phosphorylation
|
HDAC9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235813 |
Ser240 |
KVAERRSsPLLRRKD |
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 15546868 |
Mirk activated mef2 not through direct phosphorylation of mef2 but by phosphorylation of its inhibitors, the class ii histone deacetylases (hdacs). Mef2 is sequestered by class ii hdacs such as hdac5 and mef2-interacting transcriptional repressor (mitr). Mirk antagonized the inhibition of mef2c by mitr, whereas kinase-inactive mirk was ineffective. Mirk phosphorylates class ii hdacs at a conserved site within the nuclear localization region, reducing their nuclear accumulation in a dose-dependent and kinase-dependent manner |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
DYRK1B | up-regulates
phosphorylation
|
HNF1A |
0.517 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-86728 |
Ser249 |
IQRGVSPsQAQGLGS |
Homo sapiens |
|
| pmid |
sentence |
| 11980910 |
Mirk phosphorylates hnf1 at amino acid 249mkk3 enhanced mirk kinase activity and the transcriptional activation of hnf1alpha by mirk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
DYRK1B | down-regulates activity
phosphorylation
|
HDAC5 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235809 |
Ser279 |
KVAERRSsPLLRRKD |
Mus musculus |
|
| pmid |
sentence |
| 15546868 |
Mirk activated mef2 not through direct phosphorylation of mef2 but by phosphorylation of its inhibitors, the class ii histone deacetylases (hdacs). Mef2 is sequestered by class ii hdacs such as hdac5 and mef2-interacting transcriptional repressor (mitr). Mirk antagonized the inhibition of mef2c by mitr, whereas kinase-inactive mirk was ineffective. Mirk phosphorylates class ii hdacs at a conserved site within the nuclear localization region, reducing their nuclear accumulation in a dose-dependent and kinase-dependent mannermirk phosphorylates hdac5 at ser-279 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAPK1 | up-regulates activity
phosphorylation
|
DYRK1B |
0.376 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276937 |
Ser421 |
YEPAARIsPLGALQH |
in vitro |
|
| pmid |
sentence |
| 26346493 |
S421 resides within a Ser-Pro phosphoacceptor motif that is typical for ERK1/2 and recombinant ERK2 phosphorylated DYRK1B at S421 in vitro. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
DYRK1B | down-regulates activity
phosphorylation
|
GYS1 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260633 |
Ser641 |
YRYPRPAsVPPSPSL |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 14593110 |
DYRK Family Protein Kinases Phosphorylate and Inactivate Glycogen Synthase. both protein kinases phosphorylate site 3a but no other sites that affect glycogen synthase activity. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
DYRK1B | down-regulates
phosphorylation
|
CCND1 |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235801 |
Thr288 |
VDLACTPtDVRDVDI |
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 15546868 |
Mirk activated mef2 not through direct phosphorylation of mef2 but by phosphorylation of its inhibitors, the class ii histone deacetylases (hdacs). Mef2 is sequestered by class ii hdacs such as hdac5 and mef2-interacting transcriptional repressor (mitr). Mirk antagonized the inhibition of mef2c by mitr, whereas kinase-inactive mirk was ineffective. Mirk phosphorylates class ii hdacs at a conserved site within the nuclear localization region, reducing their nuclear accumulation in a dose-dependent and kinase-dependent manner |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150126 |
Thr288 |
VDLACTPtDVRDVDI |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17046823 |
Further, we found that not only gsk-3beta but also dyrk1b modulates cyclin d1 subcellular localization by the phosphorylation of thr(288). These results suggest that dif-3 induces degradation of cyclin d1 through the gsk-3beta- and dyrk1b-mediated threonine phosphorylation in hela cells |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
DYRK1B | up-regulates
phosphorylation
|
DYRK1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79806 |
Tyr271 |
CQLGQRIyQYIQSRF |
Homo sapiens |
|
| pmid |
sentence |
| 10910078 |
Mirk kinase is activated by autophosphorylation on tyrosine at the y271/y273 site |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79810 |
Tyr273 |
LGQRIYQyIQSRFYR |
Homo sapiens |
|
| pmid |
sentence |
| 10910078 |
Mirk kinase is activated by autophosphorylation on tyrosine at the y271/y273 site |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RANBP9 | down-regulates activity
binding
|
DYRK1B |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238008 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14500717 |
Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DYRK1B | up-regulates 
|
MEF2C |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235816 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 15546868 |
Mirk activated mef2 not through direct phosphorylation of mef2 but by phosphorylation of its inhibitors, the class ii histone deacetylases (hdacs). Mef2 is sequestered by class ii hdacs such as hdac5 and mef2-interacting transcriptional repressor (mitr). Mirk antagonized the inhibition of mef2c by mitr, whereas kinase-inactive mirk was ineffective. Mirk phosphorylates class ii hdacs at a conserved site within the nuclear localization region, reducing their nuclear accumulation in a dose-dependent and kinase-dependent manner |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
MAP2K3 | up-regulates
phosphorylation
|
DYRK1B |
0.355 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-86731 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11980910 |
Mkk3 enhanced mirk kinase activity. Mkk3 possibly activates mirk by phosphorylating it. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
DCAF7 | up-regulates activity
binding
|
DYRK1B |
0.752 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260631 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 14593110 |
Two isoforms of DYRK, DYRK1A and DYRK1B, co-immunoprecipitate with HAN11 when coexpressed in COS cells indicating that the proteins interact in mammalian cells. HAN11 might target DYRKs to cytosolic locations for regulation of specific cellular functions. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
DYRK1B | down-regulates 
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235731 |
|
|
Mus musculus |
C2C12 Cell, Myoblast, Myofibroblast |
| pmid |
sentence |
| 15851482 |
Mirk diminishes the extent of myoblast apoptosis during the differentiation process, at least in part by direct modulation of p21cip1 localization. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Myotube |
3.0
DYRK1B
- 
- 