| + |
LATS2 | up-regulates 
phosphorylation
|
YWHAG |
0.336 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170139 |
Ser59 |
VVGARRSsWRVISSI |
Homo sapiens |
|
| pmid |
sentence |
| 21118956 |
Phosphorylation of 14-3-3_ on s59 by lats2. Ser(58) phosphorylation and lys(49) acetylation of 14-3-3_ occur in a coordinated time-dependent manner to regulate 14-3-3_ homodimerization. 14-3-3_ ser(58) phosphorylation is required for star interactions under control conditions, |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205247 |
Ser59 |
VVGARRSsWRVISSI |
Homo sapiens |
|
| pmid |
sentence |
| 25086053 |
Phosphorylation of 14-3-3_ on s59 by lats2. Ser(58) phosphorylation and lys(49) acetylation of 14-3-3_ occur in a coordinated time-dependent manner to regulate 14-3-3_ homodimerization. 14-3-3_ ser(58) phosphorylation is required for star interactions under control conditions, |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
YWHAG | up-regulates quantity by stabilization
binding
|
GEM |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261723 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 14701738 |
In order to address whether Gem binds specific isoforms of 14-3-3, we determined the coassociation of Gem and 14-3-3 in the neuroblastoma cell line SY5Y. 14-3-3ζ, -γ, -τ, and -β were observed to bind to Gem. 14-3-3-bound Gem has a twofold-longer half-life than nonbound Gem (Fig. (Fig.6).6). A similar increase in protein stability following 14-3-3 binding has been described for the Wee1 kinase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261713 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 14701738 |
In order to address whether Gem binds specific isoforms of 14-3-3, we determined the coassociation of Gem and 14-3-3 in the neuroblastoma cell line SY5Y. 14-3-3ζ, -γ, -τ, and -β were observed to bind to Gem. 14-3-3-bound Gem has a twofold-longer half-life than nonbound Gem (Fig. (Fig.6).6). A similar increase in protein stability following 14-3-3 binding has been described for the Wee1 kinase |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
| + |
YWHAG | down-regulates activity 
binding
|
NEFL |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252400 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23230147 |
These results suggest the important role of 14-3-3 in the dynamic regulation of NF-L assembly, and in the capacity to prevent the formation of NF-L aggregates. all seven isoforms specifically interacted with NF-L, but not NF-M or NF-H. specific interaction of 14-3-3 proteins with phosphorylated NF-L subunits also indicated the role of 14-3-3 and NF-L phosphorylation in the disassembly of neurofilaments. What is more, binding of 14-3-3 to phosphorylated NF-L subunits may prevent the dephosphorylation of these subunits by phosphatases, maintaining the hyperphosphorylation state of the subunits, which facilitates the disassembly of neurofilaments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
YWHAG
- 
- 