| + |
LATS2 | down-regulates 
phosphorylation
|
YAP1 |
0.815 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197655 |
Ser127 |
PQHVRAHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22658639 |
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198514 |
Ser127 |
PQHVRAHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22863277 |
Lats1/2 inhibit yap by direct phosphorylation at s127, which results in yap binding to 14-3-3 and cytoplasmic sequestration |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
LATS2 | down-regulates activity
phosphorylation
|
MTF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275475 |
Ser152 |
EGCPRTYsTAGNLRT |
|
|
| pmid |
sentence |
| 35027733 |
The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1|the Hippo pathway kinase LATS phosphorylates and inhibits MTF1|LATS phosphorylates MTF1 at S152 and disrupts its association with the promoters of heavy metal response genes, resulting in the loss of heavy metal response gene expression |
|
| Publications: |
1 |
| + |
LATS2 | down-regulates activity
phosphorylation
|
AMOTL2 |
0.718 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272084 |
Ser159 |
HGHVRSLsERLLQLS |
|
|
| pmid |
sentence |
| 24225952 |
The N-terminal regions of Amot proteins contain a conserved HXRXXS consensus site for LATS1/2-mediated phosphorylation.|Amot family members. Knockdown of LATS1 and LATS2 endogenously reduced the phosphorylation of Amots detected by the phospho-specific antibodies. Mutation of the serine to alanine within this HXRXXS site in Amot and AmotL2 established that this site was essential for Hippo core kinase-mediated phosphorylation. Wild-type and non-phosphorylated Amot (Amot-S175A) were targeted to actin filaments, whereas phospho-mimic Amot (Amot-S175D) failed to be localized with actin. |
|
| Publications: |
1 |
| + |
LATS2 | up-regulates quantity by stabilization 
phosphorylation
|
AMOT |
0.532 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275846 |
Ser175 |
QGHVRSLsERLMQMS |
|
|
| pmid |
sentence |
| 24101513 |
Here low serum and high LATS1 activity are found to enhance the levels of the 130-kDa isoform of angiomotin (Amot130) through phosphorylation by LATS1/2 at serine 175, which then forms a binding site for 14-3-3. Such phosphorylation, in turn, enables the ubiquitin ligase atrophin-1 interacting protein (AIP)4 to bind, ubiquitinate, and stabilize Amot130 |
|
| Publications: |
1 |
| + |
LATS2 | down-regulates quantity by destabilization
phosphorylation
|
PRPS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276504 |
Ser285 |
EDKMKHCsKIQVIDI |
in vitro |
|
| pmid |
sentence |
| 34465890 |
Recruitment of TRAF2 to PRPS1/2 requires phosphorylation of PRPS1 S285 or PRPS2 T285, which is mediated by low stiffness-activated large tumor suppressor (LATS)1/2 kinases.LATS1/2-dependent S/T285 phosphorylation is required for PRPS1/2 ubiquitination and degradation at low stiffness. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
AURKA | up-regulates
phosphorylation
|
LATS2 |
0.388 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175939 |
Ser380 |
ATLARRDsLQKPGLE |
Homo sapiens |
|
| pmid |
sentence |
| 21822051 |
In the present study, aurora a was demonstrated to phosphorylate lats2 on serine 380 (s380) during mitosistogether, the results suggest that the aurora a-lats1/2-aurora b axis might be a novel pathway that regulates accurate mitotic progression by ensuring the proper mitotic localization of lats2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124830 |
Ser83 |
ALREIRYsLLPFANE |
Homo sapiens |
|
| pmid |
sentence |
| 15147269 |
On the basis of these observations, we conclude that s83 of lats2 is a phosphorylation target of aurora-a and this phosphorylation plays a role of the centrosomal localization of lats2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
LATS2 | down-regulates quantity by destabilization
phosphorylation
|
YAP1 |
0.815 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-218038 |
Ser397 |
TYHSRDEsTDSGLSM |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20048001 |
We show that YAP is phosphorylated by Lats on Ser 381 in one of the HXRXXS motifs, and this phosphorylation provides the priming signal for CK1delta/epsilon to phosphorylate a phosphodegron in YAP. The phosphorylated phosphodegron recruits beta-TRCP, leading to YAP ubiquitination and degradation under conditions of elevated Hippo pathway activity, such as cell contact inhibition |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
LATS2 | up-regulates
phosphorylation
|
YWHAG |
0.336 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170139 |
Ser59 |
VVGARRSsWRVISSI |
Homo sapiens |
|
| pmid |
sentence |
| 21118956 |
Phosphorylation of 14-3-3_ on s59 by lats2. Ser(58) phosphorylation and lys(49) acetylation of 14-3-3_ occur in a coordinated time-dependent manner to regulate 14-3-3_ homodimerization. 14-3-3_ ser(58) phosphorylation is required for star interactions under control conditions, |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205247 |
Ser59 |
VVGARRSsWRVISSI |
Homo sapiens |
|
| pmid |
sentence |
| 25086053 |
Phosphorylation of 14-3-3_ on s59 by lats2. Ser(58) phosphorylation and lys(49) acetylation of 14-3-3_ occur in a coordinated time-dependent manner to regulate 14-3-3_ homodimerization. 14-3-3_ ser(58) phosphorylation is required for star interactions under control conditions, |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
STK4 | up-regulates
phosphorylation
|
LATS2 |
0.62 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201298 |
Ser872 |
HQRCLAHsLVGTPNY |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
MST1/2 directly phosphorylate Lats1/2 at the hydrophobic motif (Lats1 T1079 and Lats2 T1041), and this phosphorylation is required for Lats1/2 activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175821 |
Ser872 |
HQRCLAHsLVGTPNY |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175825 |
Thr1041 |
EHAFYEFtFRRFFDD |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201302 |
Thr1041 |
EHAFYEFtFRRFFDD |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
MST1/2 directly phosphorylate Lats1/2 at the hydrophobic motif (Lats1 T1079 and Lats2 T1041), and this phosphorylation is required for Lats1/2 activation |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK3 | up-regulates
phosphorylation
|
LATS2 |
0.592 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175797 |
Ser872 |
HQRCLAHsLVGTPNY |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201274 |
Ser872 |
HQRCLAHsLVGTPNY |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
MST1/2 directly phosphorylate Lats1/2 at the hydrophobic motif (Lats1 T1079 and Lats2 T1041), and this phosphorylation is required for Lats1/2 activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201278 |
Thr1041 |
EHAFYEFtFRRFFDD |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
MST1/2 directly phosphorylate Lats1/2 at the hydrophobic motif (Lats1 T1079 and Lats2 T1041), and this phosphorylation is required for Lats1/2 activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175801 |
Thr1041 |
EHAFYEFtFRRFFDD |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
LATS2 | down-regulates
phosphorylation
|
WWTR1 |
0.686 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197651 |
Ser89 |
AQHVRSHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22658639 |
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175787 |
Ser89 |
AQHVRSHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activated lats1/2 in turn phosphorylate and inhibit yap/taz transcription co-activators |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
LATS2 | down-regulates activity
phosphorylation
|
ABL1 |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276497 |
Thr178 |
VYHYRINtASDGKLY |
in vitro |
|
| pmid |
sentence |
| 23852372 |
Inhibition of c-Abl by Lats2 was mediated through Lats2 interaction with and phosphorylation of c-Abl. Lats2 phosphorylates c-Abl at Thr197 in vitro. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
LATS2 | up-regulates
phosphorylation
|
SNAI1 |
0.543 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176647 |
Thr203 |
QGHVRTHtGEKPFSC |
Homo sapiens |
|
| pmid |
sentence |
| 21952048 |
Lats2 kinase potentiates snail1 activity by promoting nuclear retention upon phosphorylation. during tgf_-induced emt lats2 is activated and snail1 phosphorylated at t203. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LATS2 | down-regulates quantity by destabilization
phosphorylation
|
PRPS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276507 |
Thr285 |
EDKMKHCtKIQVIDI |
in vitro |
|
| pmid |
sentence |
| 34465890 |
Recruitment of TRAF2 to PRPS1/2 requires phosphorylation of PRPS1 S285 or PRPS2 T285, which is mediated by low stiffness-activated large tumor suppressor (LATS)1/2 kinases.LATS1/2-dependent S/T285 phosphorylation is required for PRPS1/2 ubiquitination and degradation at low stiffness. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
LATS2 | up-regulates activity
phosphorylation
|
CDC26 |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275474 |
Thr7 |
tRLELKLD |
|
|
| pmid |
sentence |
| 25723520 |
LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C|Overall, these results suggest that LATS1/2 are novel kinases involved in APC/C phosphorylation and indicate a direct regulatory link between LATS1/2 and APC/C |
|
| Publications: |
1 |
| + |
Mob1 | up-regulates
binding
|
LATS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269957 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
GCG | up-regulates 
|
LATS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199205 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
On the other hand, galfas-coupled signals, such as epinephrine and glucagon, induce kinase activity of lats1/2, leading to phosphorylation and yap/taz. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LATS2 | down-regulates quantity by repression 
transcriptional regulation
|
VEPH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177071 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22055343 |
Melted represses warts transcription to disrupt hippo pathway activity and specify rh5 fate wts and melt repress each other s transcription in a double negative, bistable feedback loop that directs robust expression of either rh5 or rh6 in r9 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VEPH1 | down-regulates quantity by repression
transcriptional regulation
|
LATS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177077 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22055343 |
Melted represses warts transcription to disrupt hippo pathway activity and specify rh5 fate wts and melt repress each other s transcription in a double negative, bistable feedback loop that directs robust expression of either rh5 or rh6 in r9 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MOB1A | up-regulates
binding
|
LATS2 |
0.862 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169755 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
(R)-adrenaline | up-regulates
|
LATS2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199199 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
On the other hand, galfas-coupled signals, such as epinephrine and glucagon, induce kinase activity of lats1/2, leading to phosphorylation and yap/taz. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NF2 | up-regulates
binding
|
LATS2 |
0.716 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202607 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24012335 |
As expected, the nf2-/- fc-912 cells were defective in lats1/2 phosphorylation (figure s2e-f). Subcellular fractionation revealed a significant increase of endogenous lats1/2 in the cytoplasmic relative to the membrane fraction in the nf2-/- fc-912 schwann cells compared to the nf2+/+ fh-912 schwann cells (figure 2e). This localization defect was rescued by re-expression of nf2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK3/4 | up-regulates
phosphorylation
|
LATS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270218 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
sphingosine 1-phosphate | down-regulates
|
LATS2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198553 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22863277 |
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F2R | down-regulates
|
LATS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192048 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22972936 |
Par1 acts through g12/13 and rho gtpase to inhibit the lats1/2 kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F-actin_assembly | down-regulates
|
LATS2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192783 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23450633 |
Ga12/13 recruitment of rho-gefs causes rhoa activation and f-actin assembly, which promotes lats1/lat2 inactivation by an unknown, but myosin-independent mechanism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
AMOTL2 | up-regulates activity
relocalization
|
LATS2 |
0.718 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271875 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 34404733 |
Ubiquitinated AMOTL2 then serves as a physical docking site for LATS2, which phosphorylates YAP to promote its cytoplasmic retention and degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LATS2 | up-regulates quantity by stabilization
phosphorylation
|
SNAI1 |
0.543 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272138 |
|
|
in vitro |
|
| pmid |
sentence |
| 24157836 |
FBXL5 is located in the nucleus where it interacts with Snail1 promoting its polyubiquitination and affecting Snail1 protein stability and function by impairing DNA binding. Snail1 is ubiquitinated by the SCFFBXL5 complex. Snail1 downregulation by FBXL5 is prevented by Lats2, a protein kinase that phosphorylates Snail1 precluding its nuclear export but not its polyubiquitination. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
DCAF1 | down-regulates quantity by destabilization
binding
|
LATS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272227 |
|
|
Homo sapiens |
H-MESO-1 Cell |
| pmid |
sentence |
| 25026211 |
CRL4 DCAF1 ubiquitylates and inhibits Lats. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MOB1B | up-regulates
binding
|
LATS2 |
0.872 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169798 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
PRKACA | up-regulates
phosphorylation
|
LATS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236994 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 23644383 |
Here, we show that cyclic amp (camp)-dependent protein kinase (pka) phosphorylates lats and thereby enhances its activity sufficiently to phosphorylate yap on ser381. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
lysophosphatidic acids | down-regulates
|
LATS2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198520 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 22863277 |
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Cullin4-RBX1-DDB1 | down-regulates quantity by destabilization
ubiquitination
|
LATS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272230 |
|
|
Homo sapiens |
H-MESO-1 Cell |
| pmid |
sentence |
| 25026211 |
CRL4 DCAF1 ubiquitylates and inhibits Lats. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
LATS2
- 
- 