Relation Results

Summary

Name KCNJ2
Full Name Inward rectifier potassium channel 2
Synonyms Cardiac inward rectifier potassium channel, Inward rectifier K(+) channel Kir2.1, IRK-1, hIRK1, Potassium channel, inwardly rectifying subfamily J member 2 | IRK1
Primary ID P63252
Links - -
Type protein
Relations 2
Function Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels a ...
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Type: Score: Layout: SPV 
0.20.2PRKACAKCNJ2PKA

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKACAdown-regulates activity img/direct_inhibition.png phosphorylation KCNJ2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276267 Ser425 PRPLRREsEI in vitro
pmid sentence
PKA consensus site S425 required for PKA-mediated effects on Kir2.1 channels. PKA activation reduced outward IK1 for heteromeric Kir2.1 WT+V227F channels after 2 hours of PKA activation.
Publications: 1 Organism: In Vitro
+ PKAdown-regulates activity img/direct_inhibition.png phosphorylation KCNJ2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273779 Ser425 PRPLRREsEI in vitro
pmid sentence
KCNJ2 encodes Kir2.1, a pore-forming subunit of the cardiac inward rectifier current, I(K1). This PKA-simulated catecholaminergic stimulation caused marked reduction of outward I(K1) compared with Kir2.1-WT. PKA-induced reduction in I(K1) was eliminated by mutating the phosphorylation site at serine 425 (S425N).
Publications: 1 Organism: In Vitro
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