+ |
CSNK2A1 | up-regulates activity
phosphorylation
|
EIF4G2 |
0.227 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266384 |
Ser902 |
ETAEEEEsEEEAD |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
29530922 |
DAP5(S902) is phosphorylated by CK2α. Phosphorylation of DAP5(S902) by CK2α is required for eIF2β binding. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CDK1 | up-regulates activity
phosphorylation
|
EIF4G2 |
0.346 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266387 |
Thr508 |
AQPPRTQtPPLGQTP |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
29530922 |
To test whether CDK1 phosphorylates T508, Flag-DAP5 was purified from dox-induced HEK293 cells and incubated with active recombinant JNK2 or CDK1 in the presence of ATP (Fig. 3G). DAP5(T508) was phosphorylated only upon incubation with CDK1 (Fig. 3G). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
EIF3_complex | up-regulates activity
stabilization
|
EIF4G2 |
0.392 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269156 |
|
|
Homo sapiens |
|
pmid |
sentence |
17581632 |
EIF3 plays many functions in initiation complex formation. It interacts with eIF1, eIF5, eIF4B and eIF4G, and the direct interaction between eIF3 and eIF4G may serve as a bridge between the 40S ribosomal subunit and eIF4F-bound mRNA (Hershey and Merrick, 2000). eIF3 stabilizes the binding of the eIF2-GTP-Met-tRNAiMet ternary complex to the 40S subunit |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
EIF4G2 | up-regulates activity
binding
|
EIF2S2 |
0.743 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266385 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
29530922 |
Unlike eIF4GI/II, DAP5 binds eIF2β, a subunit of the eIF2 complex that delivers methionyl-tRNA to ribosomes. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |