Relation Results

Summary

Name EIF4G2
Full Name Eukaryotic translation initiation factor 4 gamma 2
Synonyms eIF-4-gamma 2, eIF-4G 2, eIF4G 2, Death-associated protein 5, DAP-5, p97 | DAP5
Primary ID P78344
Links - -
Type protein
Relations 4
Function Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some ca ...
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Type: Score: Layout: SPV 
0.2270.3430.390.747CSNK2A1EIF4G2CDK1EIF3_complexEIF2S2

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CSNK2A1up-regulates activity img/direct-activation.png phosphorylation EIF4G2 0.227
Identifier Residue Sequence Organism Cell Line
SIGNOR-266384 Ser902 ETAEEEEsEEEAD Homo sapiens HEK-293 Cell
pmid sentence
DAP5(S902) is phosphorylated by CK2α. Phosphorylation of DAP5(S902) by CK2α is required for eIF2β binding.
Publications: 1 Organism: Homo Sapiens
+ CDK1up-regulates activity img/direct-activation.png phosphorylation EIF4G2 0.343
Identifier Residue Sequence Organism Cell Line
SIGNOR-266387 Thr508 AQPPRTQtPPLGQTP Homo sapiens HEK-293 Cell
pmid sentence
To test whether CDK1 phosphorylates T508, Flag-DAP5 was purified from dox-induced HEK293 cells and incubated with active recombinant JNK2 or CDK1 in the presence of ATP (Fig. 3G). DAP5(T508) was phosphorylated only upon incubation with CDK1 (Fig. 3G).
Publications: 1 Organism: Homo Sapiens
+ EIF3_complexup-regulates activity img/direct-activation.png stabilization EIF4G2 0.39
Identifier Residue Sequence Organism Cell Line
SIGNOR-269156 Homo sapiens
pmid sentence
EIF3 plays many functions in initiation complex formation. It interacts with eIF1, eIF5, eIF4B and eIF4G, and the direct interaction between eIF3 and eIF4G may serve as a bridge between the 40S ribosomal subunit and eIF4F-bound mRNA (Hershey and Merrick, 2000). eIF3 stabilizes the binding of the eIF2-GTP-Met-tRNAiMet ternary complex to the 40S subunit
Publications: 1 Organism: Homo Sapiens
+ EIF4G2up-regulates activity img/direct-activation.png binding EIF2S2 0.747
Identifier Residue Sequence Organism Cell Line
SIGNOR-266385 Homo sapiens HEK-293 Cell
pmid sentence
Unlike eIF4GI/II, DAP5 binds eIF2β, a subunit of the eIF2 complex that delivers methionyl-tRNA to ribosomes.
Publications: 1 Organism: Homo Sapiens
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