3.0
Summary
| Name |  EIF2S2View Modifications |
| Full Name | Eukaryotic translation initiation factor 2 subunit 2 |
| Synonyms | Eukaryotic translation initiation factor 2 subunit beta, eIF-2-beta | EIF2B |
| Primary ID | P20042 |
| Links |  -  -  |
| Type | protein |
| Relations | 10 |
| Function | eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | up-regulates 
phosphorylation
|
EIF2S2 | 0.355 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | EIF2B2 | up-regulates activity
guanine nucleotide exchange factor
|
EIF2S2 | 0.74 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EIF2S2 | up-regulates quantity
translation regulation
|
EGLN1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EIF2B4 | up-regulates activity
guanine nucleotide exchange factor
|
EIF2S2 | 0.744 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EIF2B5 | up-regulates activity
guanine nucleotide exchange factor
|
EIF2S2 | 0.873 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EIF2S2 | form complex 
binding
|
Ternary_GTP_eIF2_tRNA_complex | 0.954 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EIF4G2 | up-regulates activity
binding
|
EIF2S2 | 0.743 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EIF2B3 | up-regulates activity
guanine nucleotide exchange factor
|
EIF2S2 | 0.842 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EIF2B1 | up-regulates activity
guanine nucleotide exchange factor
|
EIF2S2 | 0.77 |
| Publications: | 1 | Organism: | Homo Sapiens | |