3.0
Summary
| Name |  ASIC1View Modifications |
| Full Name | Acid-sensing ion channel 1 |
| Synonyms | ASIC1, Amiloride-sensitive cation channel 2, neuronal, Brain sodium channel 2, BNaC2 | ACCN2, BNAC2 |
| Primary ID | P78348 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. |
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phosphorylation
relocalization