| + |
6 | down-regulates activity 
binding
|
RAE1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260975 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32353859 |
Orf6 of SARS-CoV antagonizes host interferon signaling by perturbing nuclear transport, and the NUP98-RAE1 interaction with Orf6 may perform the same function for SARS-CoV-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAE1 | up-regulates activity 
binding
|
NUP98 |
0.882 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260868 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16036565 |
Nup98 is a major interacting partner of Rae1 and known to beinvolved in mRNA export. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Interferon-type-I | up-regulates quantity by expression 
transcriptional regulation
|
RAE1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260869 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16036565 |
Nup98/Nup96 (41) and Rae1 (17)are up regulated by interferons, which revert the mRNAexport block induced by VSV M protein |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAE1 | form complex 
binding
|
NPC |
0.569 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262095 |
|
|
|
|
| pmid |
sentence |
| 27016207 |
The protein inventory of the NPC has been studied for a very diverse set of eukaryotes, including trypanosomes, fungi, plants, animals, and humans [4], [5], [6], [7], [8], [9]. In all cases, about 30 different Nups were found (Fig. 2). |
|
| Publications: |
1 |
| + |
RAE1 | up-regulates
|
mRNA-nucleus_export |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260871 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20498086 |
The export of mRNAs is a multistep process, involving the packaging of mRNAs into messenger ribonucleoprotein particles (mRNPs), their transport through nuclear pore complexes, and mRNP remodeling events prior to translation. Ribonucleic acid export 1 (Rae1) and Nup98 are evolutionarily conserved mRNA export factors that are targeted by the vesicular stomatitis virus matrix protein to inhibit host cell nuclear export. these data suggest that the Rae1*Nup98 complex directly binds to the mRNP at several stages of the mRNA export pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RAE1
- 
- 