Summary

Name 6
Full Name Non-structural protein 6
Synonyms ns6, Accessory protein 6, Protein X3 |
Primary ID P59634
Links - -
Type protein
Relations 7
Pathways COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV ATTACHMENT AND ENTRY, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES
Function Could be a determinant of virus virulence, since, when expressed in an otherwise attenuated JHM strain of murine coronavirus, it can dramatically increase the lethality of the latter. Seems to stimulate cellular DNA synthesis in vitro.

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Relations

Regulator Mechanism target score
+ down-regulates activity img/indirect_inhibition.png DDX58 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES
+ down-regulates activity img/indirect_inhibition.png relocalization STAT1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ down-regulates activity img/direct_inhibition.png binding NUP98 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RAE1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png IRF3 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation Interferon-type-I 0.2
Publications: 1
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA
+ up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV STRESS GRANULES