Summary

Name BTG2
Full Name Protein BTG2
Synonyms BTG family member 2, NGF-inducible anti-proliferative protein PC3 | PC3
Primary ID P78543
Links - -
Type protein
Relations 7
Function Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOD1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOD2 0.378
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation KLK3 0.2
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CAT 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NFE2L2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BTG2 0.385
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding HOXB9 0.672
Publications: 1 Organism: Homo Sapiens