Summary

Name CRADD
Full Name Death domain-containing protein CRADD
Synonyms Caspase and RIP adapter with death domain, RIP-associated protein with a death domain | RAIDD
Primary ID P78560
Links - -
Type protein
Relations 1
Function Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:9044836, PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253).

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding Caspase-2 PIDDosome 0.92
Publications: 1 Organism: Homo Sapiens