Summary

Name HLA-DRB3
Full Name HLA class II histocompatibility antigen, DR beta 3 chain
Synonyms MHC class II antigen DRB3 |
Primary ID P79483
Links - -
Type protein
Relations 4
Function A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB3-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:2788702, PubMed:2463305, PubMed:16148104, PubMed:19531622, PubMed:20368442, PubMed:19830726, PubMed:23569328, PubMed:22929521, PubMed:30282837, PubMed:31020640, PubMed:31333679, PubMed:31308093). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (By similarity). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (By similarity). The selection of the immunodominant epitopes follows two processing modes

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ MARCHF1down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination HLA-DRB3 0.2
Publications: 1 Organism: Homo Sapiens
+ MARCHF8down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination HLA-DRB3 0.2
Publications: 1 Organism: Homo Sapiens
+ CIITAup-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DRB3 0.2
Publications: 1 Organism: Homo Sapiens
+ RFX complexup-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DRB3 0.2
Publications: 1 Organism: In Vitro