4.0
Summary
| Name |  MARCHF8View Modifications |
| Full Name | E3 ubiquitin-protein ligase MARCHF8 |
| Synonyms | Cellular modulator of immune recognition, c-MIR, Membrane-associated RING finger protein 8, Membrane-associated RING-CH protein VIII, MARCH-VIII, RING finger protein 178, RING-type E3 ubiquitin transferase MARCH8 | MIR, RNF178 |
| Primary ID | Q5T0T0 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MARCHF8 | down-regulates quantity by destabilization 
polyubiquitination
|
HLA-DRA | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MARCHF8 | down-regulates quantity by destabilization
polyubiquitination
|
HLA-DRB4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MARCHF8 | down-regulates quantity by destabilization
polyubiquitination
|
HLA-DRB3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MARCHF8 | down-regulates quantity
ubiquitination
|
TNFRSF10A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity 
ubiquitination
|
MARCHF8 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MARCHF8 | down-regulates quantity by destabilization
ubiquitination
|
CDH1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MARCHF8 | down-regulates quantity by destabilization
polyubiquitination
|
SLC3A2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |