| + |
SIM1 | down-regulates activity 
binding
|
ARNT |
0.545 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240756 |
|
|
in vitro |
|
| pmid |
sentence |
| 9020169 |
SIM1 can inhibit AHR·ARNT binding to the XRE and can inhibit expression from an XRE-driven reporter gene indicates that SIM1 may act as negative regulator of transcription as well as a positive regulator. The above inhibitory effects may result from SIM1 competing with AHR for binding to ARNT, although we cannot exclude the possibility that SIM1 may also have other inhibitory effects of AHR·ARNT activity. In a similar fashion, SIM1 may act as a negative regulator of all ARNT-dependent genes. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SIM1 | down-regulates activity
binding
|
AHR-ARNT |
0.42 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240811 |
|
|
in vitro |
|
| pmid |
sentence |
| 9020169 |
SIM1 can inhibit AHR·ARNT binding to the XRE and can inhibit expression from an XRE-driven reporter gene indicates that SIM1 may act as negative regulator of transcription as well as a positive regulator. The above inhibitory effects may result from SIM1 competing with AHR for binding to ARNT, although we cannot exclude the possibility that SIM1 may also have other inhibitory effects of AHR·ARNT activity. In a similar fashion, SIM1 may act as a negative regulator of all ARNT-dependent genes. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SIM1 | up-regulates activity 
binding
|
ARNT |
0.545 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240759 |
|
|
in vitro |
|
| pmid |
sentence |
| 9020169 |
We demonstrate that both SIM1 and SIM2 can heterodimerize via their helix-loop-helix·PAS regions with ARNT, but not with AHR, and that they do not form homodimers. Furthermore, SIM1 may have a dual role, both negatively affecting AHR·ARNT binding to the XRE and also acting in concert with ARNT as a novel DNA-binding heterodimer. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
SIM1
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