| + |
CSNK2A1 | down-regulates 
phosphorylation
|
ARNT |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140034 |
Ser77 |
DKERFARsDDEQSSA |
Homo sapiens |
|
| pmid |
sentence |
| 16129408 |
Here, we show that arnt and alt arnt proteins are differentially phosphorylated by protein kinase ckii in vitro. Phosphorylation had an inhibitory effect on dna-binding to an e-box probe by alt arnt, but not arnt, homodimers. This inhibitory phosphorylation occurs through ser77. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIM1 | down-regulates activity
binding
|
ARNT |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240756 |
|
|
in vitro |
|
| pmid |
sentence |
| 9020169 |
SIM1 can inhibit AHR·ARNT binding to the XRE and can inhibit expression from an XRE-driven reporter gene indicates that SIM1 may act as negative regulator of transcription as well as a positive regulator. The above inhibitory effects may result from SIM1 competing with AHR for binding to ARNT, although we cannot exclude the possibility that SIM1 may also have other inhibitory effects of AHR·ARNT activity. In a similar fashion, SIM1 may act as a negative regulator of all ARNT-dependent genes. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
ARNT | up-regulates activity 
binding
|
HIF1A |
0.784 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253720 |
|
|
|
|
| pmid |
sentence |
| 14764593 |
The functional transcription factor exists as a heterodimeric complex consisting of HIF-1alpha and the aryl hydrocarbon receptor nuclear translocator (ARNT). Association of HIF-1 with ARNT is required for its activity; however, no other role has been ascribed to this interaction. |
|
| Publications: |
1 |
| + |
ARNT | form complex 
binding
|
HIF-1 complex |
0.784 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267448 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
HIF-1 consists of two subunits, HIF-1α and HIF-1β. While HIF-1β protein is constitutively expressed and present in excess, HIF-1α protein has a short half-life |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARNT | down-regulates quantity by repression 
transcriptional regulation
|
CDK2 |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253693 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 21544813 |
Screening by quantitative reverse-transcription PCR and PCR arrays revealed that cyclin E1, CDK2, Fos and Jun were negatively regulated by ARNT, whereas CDKN1C, CNKN2A, CDKN2B, MAPK11 and MAPK14 were positively regulated in HCC |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROS | up-regulates quantity by expression 
|
ARNT |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253689 |
|
|
|
|
| pmid |
sentence |
| 22387692 |
Although the regulation mechanism of the ARNT expression is largely unknown, earlier studies reported that the human ARNT protein level was decreased by hydrogen peroxide or reactive oxygen species. |
|
| Publications: |
1 |
| + |
SIM1 | up-regulates activity
binding
|
ARNT |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240759 |
|
|
in vitro |
|
| pmid |
sentence |
| 9020169 |
We demonstrate that both SIM1 and SIM2 can heterodimerize via their helix-loop-helix·PAS regions with ARNT, but not with AHR, and that they do not form homodimers. Furthermore, SIM1 may have a dual role, both negatively affecting AHR·ARNT binding to the XRE and also acting in concert with ARNT as a novel DNA-binding heterodimer. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
ARNT | down-regulates quantity by repression
transcriptional regulation
|
TH |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253701 |
|
|
Mus musculus |
MN-9D Cell |
| pmid |
sentence |
| 17457889 |
Overexpression and siRNA experiments revealed that NPAS1, in concert with ARNT, negatively regulates the expression of TH and that this regulation is mediated by a direct binding of NPAS1 on the TH promoter. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ARNT | up-regulates quantity by expression
transcriptional regulation
|
CA9 |
0.521 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253706 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22387692 |
The miR-24-dependent down-regulation of ARNT decreased the expression of its downstream genes such as CYP1A1 and carbonic anhydrase IX. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARNT | down-regulates quantity by repression
transcriptional regulation
|
CCNE1 |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253692 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 21544813 |
Screening by quantitative reverse-transcription PCR and PCR arrays revealed that cyclin E1, CDK2, Fos and Jun were negatively regulated by ARNT, whereas CDKN1C, CNKN2A, CDKN2B, MAPK11 and MAPK14 were positively regulated in HCC |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARNT | up-regulates quantity by expression
transcriptional regulation
|
CYP1B1 |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253740 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 16115918 |
Expressions of CYP1B1 mRNA and protein were increased in prostate cancer. The aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) heterodimer complex activates gene transcription by binding to the DREs of CYP1B1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARNT | form complex
binding
|
AHR-ARNT |
0.752 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240814 |
|
|
in vitro |
|
| pmid |
sentence |
| 9020169 |
SIM1 and SIM2, and the mammalian aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) proteins are members of the basic-helix-loop-helix·PAS family of transcription factors. In the yeast two-hybrid system, we demonstrate strong constitutive interaction of ARNT with SIM1 and SIM2 and fully ligand-dependent interaction of ARNT with AHR. SIM1 inhibits binding of the AHR·ARNT dimer to the xenobiotic response element in vitro Introduction of SIM1 into hepatoma cells inhibits transcriptional transactivation by the endogenous AHR·ARNT dimer. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
ARNT | down-regulates quantity by repression
transcriptional regulation
|
JUN |
0.569 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253697 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 21544813 |
Screening by quantitative reverse-transcription PCR and PCR arrays revealed that cyclin E1, CDK2, Fos and Jun were negatively regulated by ARNT, whereas CDKN1C, CNKN2A, CDKN2B, MAPK11 and MAPK14 were positively regulated in HCC |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARNT | down-regulates quantity by repression
transcriptional regulation
|
FOS |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253696 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21544813 |
Screening by quantitative reverse-transcription PCR and PCR arrays revealed that cyclin E1, CDK2, Fos and Jun were negatively regulated by ARNT, whereas CDKN1C, CNKN2A, CDKN2B, MAPK11 and MAPK14 were positively regulated in HCC |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARNT | up-regulates quantity by expression
transcriptional regulation
|
CYP1A1 |
0.646 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259910 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17012224 |
Kaempferol proved to be capable of inhibiting binding of agonist and agonist-induced formation of the AHR/ARNT DNA-binding complex and upregulation of the AHR target gene, CYP1A1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIM2 | up-regulates activity
binding
|
ARNT |
0.498 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240808 |
|
|
in vitro |
|
| pmid |
sentence |
| 9020169 |
We demonstrate that both SIM1 and SIM2 can heterodimerize via their helix-loop-helix·PAS regions with ARNT, but not with AHR, and that they do not form homodimers. Furthermore, SIM1 may have a dual role, both negatively affecting AHR·ARNT binding to the XRE and also acting in concert with ARNT as a novel DNA-binding heterodimer. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
ARNT | up-regulates quantity by expression
transcriptional regulation
|
CYP1A1 |
0.646 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253705 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22387692 |
The miR-24-dependent down-regulation of ARNT decreased the expression of its downstream genes such as CYP1A1 and carbonic anhydrase IX. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ARNT
- 
- 