Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-107750 |
|
|
Homo sapiens |
|
pmid |
sentence |
11350724 |
Shc exists in three different isoforms, p46shc, p52shc and p66shc which are tyrosine phosphorylated upon egf stimulation and bind to the activated egfr and grb2. Interestingly, while the 46 and 52 kda isoforms increase mitogenic signalling after egf stimulation and are able to transform nih3t3 cells (pelicci et al. 1992), p66shc has no transforming potential and negatively influences egf-induced c-fos transcription |
|