| + |
CDKL1 | up-regulates activity 
phosphorylation
|
CDKN2B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273862 |
|
|
Homo sapiens |
Colorectal Cancer Cell Line |
| pmid |
sentence |
| 28352193 |
We demonstrated that depletion of CDKL1 notably upregulated the protein expression of P15. P15 is shown to be a target of CDKL1 in CRC, either direct or indirect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDKL1 | up-regulates activity
phosphorylation
|
RB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273863 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28352193 |
We also proved that as a downstream molecule of the P15 pathway, Rb is inhibited after CDKL1 knockdown. Rb is a well-known tumor suppressor in cell cycle regulation.28 Phosphorylation of Rb negatively regulates the cell cycle through E2F repression.29–31 However, Rb contains 13 conserved sites that are phosphorylated by the CDK–P15 complex in cycling cells and phosphorylation will cause site-specific and diverse conformational changes in the complex.32,33 Further studies need to be conducted to decipher the phosphorylated site of Rb related to CDKL1 knockdown. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CDKL1
- 
- 