| + |
PLCB2 | up-regulates quantity 
|
superoxide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255013 |
|
|
|
|
| pmid |
sentence |
| 23994464 |
The PI3Kγ pathway (but not PLCβ2/3) is required for chemotaxis of the cells while both pathways are required for GPCR-induced superoxide release |
|
| Publications: |
1 |
| + |
PLCB2 | up-regulates quantity 
chemical modification
|
1D-myo-inositol 1,4,5-trisphosphate(6-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255017 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23994464 |
The first phase of this signal is likely mediated by phospholipase Cβ (PLCβ) enzymes leading to the generation of IP3 and concomitant release of Ca2+ from intracellular stores |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNB/GNG | up-regulates
|
PLCB2 |
0.528 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255015 |
|
|
|
|
| pmid |
sentence |
| 23994464 |
However, it was later shown that other PLCβ isoforms (particularly PLCβ2 and PLCβ3) can also be directly activated by Gβγ subunits |
|
| Publications: |
1 |
| + |
GNB1 | up-regulates
binding
|
PLCB2 |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-19447 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1465133 |
Activation of plc-beta 2 by beta gamma subunits may be an important mechanism by which pertussis toxin-sensitive g proteins stimulate plc. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PLCB2
- 
- 