| + |
GSK3B | up-regulates activity 
phosphorylation
|
CAP1 |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264822 |
Ser308 |
SAPKPQTsPSPKRAT |
Homo sapiens |
|
| pmid |
sentence |
| 30123351 |
We found that GSK3 phosphorylates S307 and S309 by using inhibitors LiCl. Inhibition of GSK3beta can cause loss of cell polarity as well as accumulation of stress fibers. We propose that GSK3 regulates CAP1 through at least two mechanisms. First, GSK3 (and potentially other kinases) phosphorylate CAP1 at S309 and promote CAP1 localization to the cytosol. Second, phosphorylation at S309 affects protein-protein interactions with actin and cofilin. The loss of this phospho-regulation by GSK3 inhibition is expected to disrupt CAP1 function and actin dynamics. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264823 |
Ser310 |
PKPQTSPsPKRATKK |
Homo sapiens |
|
| pmid |
sentence |
| 30123351 |
We found that GSK3 phosphorylates S307 and S309 by using inhibitors LiCl. Inhibition of GSK3beta can cause loss of cell polarity as well as accumulation of stress fibers. We propose that GSK3 regulates CAP1 through at least two mechanisms. First, GSK3 (and potentially other kinases) phosphorylate CAP1 at S309 and promote CAP1 localization to the cytosol. Second, phosphorylation at S309 affects protein-protein interactions with actin and cofilin. The loss of this phospho-regulation by GSK3 inhibition is expected to disrupt CAP1 function and actin dynamics. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Lung |
| + |
CAP1 | down-regulates activity 
|
PTK2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264824 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 30894654 |
In HeLa and metastatic breast cancer cells, depletion of CAP1 leads to activation of FAK and enhanced cell adhesion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CAP1
- 
- 