Summary

Name EWSR1
Full Name RNA-binding protein EWS
Synonyms EWS oncogene, Ewing sarcoma breakpoint region 1 protein | EWS
Primary ID Q01844
Links - -
Type protein
Relations 8
Function Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation EWSR1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EWSR1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EWSR1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EWSR1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EWSR1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EWSR1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EWSR1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding EWSR1 0.28
Publications: 1 Organism: Homo Sapiens