Summary

Name MAPK14
Full Name Mitogen-activated protein kinase 14
Synonyms MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Stress-activated protein kinase 2a, SAPK2a | CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
Primary ID Q16539
Links - -
Type protein
Relations 265
Pathways Toll like receptors, NOTCH Signaling and Myogenesis, P38 Signaling, P38 Signaling and Myogenesis, TGFbeta Signaling, TNF alpha, Glucocorticoid Receptor
Inhibitors MK2a Inhibitor; SB 202190; VX-745; SB 203580; 586379-66-0; Doramapimod; VX-702
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113'.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation HIST1H3A 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.07
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1A 0.19
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TCF3 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation TP53 0.13
Publications: 4 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.13
Publications: 6 Organism: Homo Sapiens,
Pathways:P38 Signaling
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.13
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ down-regulates img/direct_inhibition.png phosphorylation CASP3 0.38
Publications: 1 Organism: Homo Sapiens
Pathways:TNF alpha
+ up-regulates img/direct-activation.png phosphorylation BAZ1B
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PAK6 0.11
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NFATC4
Publications: 2 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png phosphorylation NFATC1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA4 0.18
Publications: 6 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMAD3
Publications: 3 Organism: Homo Sapiens, Rattus Norvegicus
Pathways:TGFbeta Signaling
+ up-regulates img/direct-activation.png phosphorylation NR3C1 0.16
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:Glucocorticoid Receptor
+ up-regulates img/direct-activation.png phosphorylation RBSN 0.05
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDC25C
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PPARGC1A 0.13
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png phosphorylation MAPKAPK2 0.58
Publications: 6 Organism: Homo Sapiens, In Vitro
Pathways:P38 Signaling
+ up-regulates activity img/direct-activation.png phosphorylation CDX2
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation F3 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PIP4K2B 0.12
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.25
Publications: 1 Organism: Homo Sapiens
Pathways:TNF alpha
+ up-regulates img/direct-activation.png phosphorylation ELK3 0.07
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA5 0.27
Publications: 5 Organism: Homo Sapiens,
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation ELK1
Publications: 4 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates activity img/direct-activation.png phosphorylation MEF2C 0.18
Publications: 5 Organism: Homo Sapiens
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.25
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation HBP1 0.07
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MEF2A 0.23
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
Pathways:P38 Signaling, P38 Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation TAB1 0.29
Publications: 3 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates activity img/indirect-activation.png unknown AKT2
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation PLA2G4A 0.30
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NCOA3 0.15
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RB1 0.16
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EIF4EBP1
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TWIST1 0.03
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOXO3
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOXO
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT4 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SLC9A1 0.21
Publications: 6 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.26
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.34
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation KRT8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FGFR1 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation JUNB 0.15
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DDIT3 0.08
Publications: 2 Organism: Homo Sapiens, In Vitro
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation EPS15 0.18
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PXN 0.17
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BCL2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATF2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTPN7
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ZNHIT1
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation ELAVL1 0.22
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAPK14 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EEA1 0.09
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation JDP2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation USF1 0.10
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation MAPK14
Publications: 8 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.61
Publications: 5 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF alpha, TGFbeta Signaling, Toll like receptors
+ up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.60
Publications: 5 Organism: Homo Sapiens, Mus Musculus
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TGFbeta Signaling, Toll like receptors
+ up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.35
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF alpha, TGFbeta Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MAPKAPK5 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MKNK1 0.22
Publications: 2 Organism: Homo Sapiens, In Vitro
+ up-regulates img/direct-activation.png phosphorylation MKNK1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MEF2A 0.23
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation MEF2A 0.23
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation EZH2
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.49
Publications: 6 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KHSRP
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation ADAM17 0.11
Publications: 1 Organism: Cricetulus Griseus
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis
+ img/unknown.png phosphorylation EWSR1 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.10
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation MAPK14 0.20
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK14 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/indirect-activation.png unknown M2 polarization
Publications: 1
+ up-regulates img/indirect-activation.png unknown MAPK14 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown MAPK14 0.13
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates activity img/direct-activation.png binding DUSP1
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling and Myogenesis
+ down-regulates activity img/indirect_inhibition.png unknown MAPK14
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation SUZ12/EZH2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MKNK2 0.15
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CFLAR
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown MAPK14 0.20
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation ZFP36
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates img/indirect-activation.png unknown MAPK14 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRC2
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.06
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown MAPK14
Publications: 2
+ up-regulates activity img/indirect-activation.png unknown MAPK14
Publications: 2
Pathways:P38 Signaling and Myogenesis, TNF alpha
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation JUNB 0.15
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown MAPK14 0.06
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDT1 0.10
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CCND1 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GATA2 0.09
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1C 0.09
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAPK14 0.29
Publications: 2 Organism: Rattus Norvegicus, Homo Sapiens
Pathways:P38 Signaling
+ down-regulates img/direct_inhibition.png phosphorylation MAX 0.16
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK14 0.30
Publications: 3 Organism: Mus Musculus, Homo Sapiens
Pathways:NOTCH Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png binding MAPK14 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COL1A1 0.10
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png binding MAPK14
Publications: 1 Organism: Mus Musculus
Pathways:Glucocorticoid Receptor
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.21
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation Fibrosis
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK14 0.12
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown MAPK14 0.01
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPKAPK3 0.21
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown MAPK10 0.54
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAPK14
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/indirect-activation.png unknown PPARG
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown Proliferation
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:TNF alpha, TGFbeta Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBB 0.15
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBA1 0.19
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RUNX2 0.07
Publications: 1 Organism: Mus Musculus
Pathways:TGFbeta Signaling
+ up-regulates activity img/indirect-activation.png phosphorylation MAPK14 0.10
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation SP7 0.06
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation DLX5 0.07
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png unknown EIF4EBP1 0.26
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png phosphorylation MAPK14
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK14 0.14
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling
+ down-regulates activity img/indirect_inhibition.png unknown MAPK14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK14
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAPK14 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown MAPK14 0.13
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Pathways:P38 Signaling and Myogenesis, TNF alpha
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.11
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png phosphorylation SMARCD3 0.07
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation MAPK14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MEF2D 0.20
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
Pathways:P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png binding MAPK14 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.05
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAP3K11 0.20
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EZH2 0.16
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/indirect-activation.png unknown MAPK14 0.15
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation MAPT 0.06
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ down-regulates activity img/indirect_inhibition.png unknown AKT2 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates activity img/indirect_inhibition.png unknown AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK14 0.06
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAPK14 0.21
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates img/indirect_inhibition.png unknown MAPK14
Publications: 1 Organism: Homo Sapiens
Pathways:Toll like receptors
+ up-regulates activity img/indirect-activation.png unknown MAPK14 0.21
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis, TNF alpha
+ down-regulates img/indirect_inhibition.png unknown MAPK14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown MAPK14
Publications: 2 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.15
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown MAPK14 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown HIF1A 0.12
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EEA1 0.09
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CCND1 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SIAH2 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation H3F3A 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown MYOD1 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation MAPK14 0.22
Publications: 1 Organism: Homo Sapiens