Summary

Name ROR1
Full Name Inactive tyrosine-protein kinase transmembrane receptor ROR1
Synonyms Neurotrophic tyrosine kinase, receptor-related 1 | NTRKR1
Primary ID Q01973
Links - -
Type protein
Relations 4
Function Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).

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Relations

Regulator Mechanism target score ℹ
+ ROR1up-regulates img/direct-activation.png phosphorylation SRC 0.323
Publications: 1 Organism: Homo Sapiens
+ WNT5Aup-regulates img/direct-activation.png binding ROR1 0.737
Publications: 3 Organism: Homo Sapiens