+ |
BMP1 | up-regulates quantity
cleavage
|
COL7A1 |
0.587 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-256338 |
Ala2821 |
RPLPSYAaDTAGSQL |
Homo sapiens |
Keratinocyte |
pmid |
sentence |
11986329 |
We show that bone morphogenetic protein-1 (BMP-1), which exhibits procollagen C-proteinase activity, cleaves the C-terminal propeptide from human procollagen VII. The cleavage occurs at the BMP-1 consensus cleavage site SYAA/DTAG within the NC-2 domain. Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
COL7A1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251920 |
|
|
Homo sapiens |
|
pmid |
sentence |
21931594 |
Egr-1 induced a time-dependent ECM gene expression program, with the number of ECM genes increasing >2.5-fold (from 16 to 41) between 24 and 48 h. Genes in this group include those coding for multiple collagens (COL4A1, COL4A2, COL11A1, COL7A1, COL10A1) |
|
Publications: |
1 |
Organism: |
Homo Sapiens |