| + |
CSNK2A1 | down-regulates activity 
phosphorylation
|
EGR1 |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250856 |
Ser378 |
RICMRNFsRSDHLTT |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 8662759 |
Casein kinase II associates with Egr-1 and acts as a negative modulator of its DNA binding and transcription activities in NIH 3T3 cells. | There are three CKII recognition sites (S376XXD, T389XE, and T516XXXD) in fragment 10. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250857 |
Thr391 |
TTHIRTHtGEKPFAC |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 8662759 |
Casein kinase II associates with Egr-1 and acts as a negative modulator of its DNA binding and transcription activities in NIH 3T3 cells. | There are three CKII recognition sites (S376XXD, T389XE, and T516XXXD) in fragment 10. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250858 |
Thr526 |
TNSFSAStGLSDMTA |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 8662759 |
Casein kinase II associates with Egr-1 and acts as a negative modulator of its DNA binding and transcription activities in NIH 3T3 cells. | There are three CKII recognition sites (S376XXD, T389XE, and T516XXXD) in fragment 10. |
|
| Publications: |
3 |
Organism: |
Mus Musculus |
| + |
EGR1 | up-regulates quantity by expression 
transcriptional regulation
|
NAB2 |
0.612 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253881 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20506119 |
In melanoma and carcinoma cells EGR1 activates NAB2 expression. we investigated the influence of EGR2 and EGR3 on NAB2 expression in melanoma and carcinoma cells. Here, we show that like EGR1, EGR2 and EGR3 induced NAB2 expression in these cells. EGR1 and EGR3 act in concert on the NAB2 promoter and are more potent activators of NAB2 transcription than EGR2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates activity 
binding
|
SF1 |
0.298 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254914 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19106114 |
GNRH1 induces expression of early growth response 1 (EGR1), which interacts with steroidogenic factor 1 (SF1) and paired-like homeodomain transcription factor 1 (PITX1) to regulate Lhb promoter activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
CHGA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254265 |
|
|
Homo sapiens |
AGS Cell |
| pmid |
sentence |
| 12456801 |
Recently, binding of specific protein 1 (Sp1) and cAMP response element binding protein (CREB) to a GC-rich element at -92/-62 has been identified as a critical step in gastrin-dependent regulation of the chromogranin A (CgA) gene in gastric epithelial cells. Here we demonstrate that binding of early growth response protein 1 (Egr-1) to the distal part of the -92/-62 site is also required for gastrin-dependent CgA transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
HPSE |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254267 |
|
|
Homo sapiens |
J-82 Cell, T-24 Cell |
| pmid |
sentence |
| 16007175 |
Promoter CpG hypomethylation and transcription factor EGR1 hyperactivate heparanase expression in bladder cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
COL4A2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251918 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21931594 |
Egr-1 induced a time-dependent ECM gene expression program, with the number of ECM genes increasing >2.5-fold (from 16 to 41) between 24 and 48 h. Genes in this group include those coding for multiple collagens (COL4A1, COL4A2, COL11A1, COL7A1, COL10A1) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.606 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263508 |
|
|
Homo sapiens |
Pulmonary Artery Smooth Muscle Cell |
| pmid |
sentence |
| 29212876 |
Previous studies have reported that the PPARγ proximal promoter contains an overlapping binding site for Egr-1, which is involved in the down-regulation of PPARγ. In the present study, we have provided direct evidence that leptin causes PPARγ reduction in primary cultured PASMC; this effect is coupled to leptin-induced ERK1/2 activation and subsequent induction of Egr-1, which further down-regulates PPARγ expression and results in PASMC proliferation. The present study confirmed that ERK1/2 signaling cascade mediated leptin-induced PPARγ reduction by up-regulation of Egr-1 in PASMC. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
GNRH1 | up-regulates activity
binding
|
EGR1 |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254918 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19106114 |
EGR1 bound to two binding sites on the LHB promoter and this binding was increased by GNRH1. Mutation of either site or knockdown of endogenous EGR1 decreased basal and/or GNRH1-regulated promoter activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
PDGFC |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254268 |
|
|
Rattus norvegicus |
Aortic Smooth Muscle |
| pmid |
sentence |
| 15247255 |
The PDGF family of ligands is comprised of A, B, C, and D chains. Here, we provide the first functional characterization of the PDGF-C promoter. We examined 797 bp of the human PDGF-C promoter and identified several putative recognition elements for Sp1, Ets Egr-1, and Smad.|These findings thus demonstrate that PDGF-C transcription, activated by FGF-2, is mediated by Egr-1 and its upstream kinase ERK.|Egr-1 and Sp1 specifically bind the PDGF-C promoter |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
NfKb-p65/p50 | up-regulates
binding
|
EGR1 |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216328 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10671503 |
The early growth response transcription factor egr-1 can also interact with rela in vitro and regulate nf-kappab transcriptional activity in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | up-regulates
binding
|
EGR1 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75001 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10671503 |
The early growth response transcription factor egr-1 can also interact with rela in vitro and regulate nf-kappab transcriptional activity in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAB2 | down-regulates quantity by repression 
transcriptional regulation
|
EGR1 |
0.612 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253886 |
|
|
Homo sapiens |
Epithelial Cell |
| pmid |
sentence |
| 20506119 |
Our results suggest that in many cells of neuroectodermal and epithelial origin EGR1, EGR2, and EGR3 activate NAB2 transcription which is in turn repressed by NAB2, thus establishing a negative feedback loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
TBXA2R |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254253 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19747485 |
Collectively, data establish that regulated WT1 followed by sequential Egr1 and Sp1 binding to elements within Prm1 mediate repression and subsequent induction of TPα during differentiation into the megakaryocytic phenotype, shedding significant insights into factors regulating TPα expression therein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | down-regulates quantity by repression
transcriptional regulation
|
FCER2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254277 |
|
|
Homo sapiens |
RAMOS Cell |
| pmid |
sentence |
| 9300687 |
Thus, Egr-1 seems to control the expression of downstream target genes not only as a transcriptional activator, but also as a repressor molecule. In B cells, Egr-1 therefore plays a critical role in integrating the short-lived signal delivered by triggering of the Ag receptor into phenotypic changes, including repression of CD95 and CD23 transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | down-regulates quantity by repression
transcriptional regulation
|
FAS |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254278 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9300687 |
Thus, Egr-1 seems to control the expression of downstream target genes not only as a transcriptional activator, but also as a repressor molecule. In B cells, Egr-1 therefore plays a critical role in integrating the short-lived signal delivered by triggering of the Ag receptor into phenotypic changes, including repression of CD95 and CD23 transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATF1 | up-regulates quantity by expression
transcriptional regulation
|
EGR1 |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271686 |
|
|
|
|
| pmid |
sentence |
| 10391889 |
Phosphorylated CREB and ATF1 then bind to the CRE of the egr-1 promoter and cause a stress-dependent transcriptional activation of this gene. |
|
| Publications: |
1 |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
COL7A1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251920 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21931594 |
Egr-1 induced a time-dependent ECM gene expression program, with the number of ECM genes increasing >2.5-fold (from 16 to 41) between 24 and 48 h. Genes in this group include those coding for multiple collagens (COL4A1, COL4A2, COL11A1, COL7A1, COL10A1) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRX1 | down-regulates quantity by repression
transcriptional regulation
|
EGR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261661 |
|
|
Homo sapiens |
SGC-7901 Cell |
| pmid |
sentence |
| 20440264 |
We identified a number of target genes by global microarray analysis after IRX1 transfection combined with real-time PCR and chromatin immunoprecipitation assay.| Downregulation of BDKRB2, PHYHIPL, HIST2H2BE, FGF7, PTGER1, NPTX1, EGR1, COL9A3, CUGBP2, DKK3 and BPI was confirmed. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates
|
Monocyte_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256088 |
|
|
Homo sapiens |
U-937 Cell |
| pmid |
sentence |
| 1864967 |
Finally, we demonstrate that dexamethasone, an inhibitor of monocytic differentiation, blocks the associated increases in EGR-1 and EGR-2 expression. Taken together, the results indicate that the EGR-1 and EGR-2 early response genes are involved in the induction of myeloid leukemia cell differentiation along the monocytic lineage and in the activation of human monocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
COL10A1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251921 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21931594 |
Egr-1 induced a time-dependent ECM gene expression program, with the number of ECM genes increasing >2.5-fold (from 16 to 41) between 24 and 48 h. Genes in this group include those coding for multiple collagens (COL4A1, COL4A2, COL11A1, COL7A1, COL10A1) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HLX | down-regulates quantity by repression
transcriptional regulation
|
EGR1 |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261621 |
|
|
Homo sapiens |
SGHPL-4 Cell |
| pmid |
sentence |
| 20008130 |
In this study, we have identified cell cycle regulatory genes as downstream targets of the homeobox gene HLX in cultured trophoblast cells, namely RB1, MYC, EGR1, CDKN1C, ELK1, CCNB1, and JUN. RB1 and MYC mRNA expression was increased with HLX inactivation, whereas EGR1, CDKN1C, ELK1, CCNB1, and JUN mRNA expression was decreased compared with mock-transfected control cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
SLC4A2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254250 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22228178 |
Cellular and molecular experiments indicated that AE2 expression promoted proliferation of colon cancer cells. In addition, we found that transcription factor EGR1 underlies AE2 upregulation and the AE2 sequester p16INK4a (P16) in the cytoplasm of colon cancer cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Colon |
| + |
DMTF1 | up-regulates quantity by expression
transcriptional regulation
|
EGR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261584 |
|
|
Mus musculus |
C-10 Cell |
| pmid |
sentence |
| 19816943 |
Notably, amphiregulin (Areg), thrombospondin-1 (Tsp-1), JunB, Egr1, adrenomedullin (Adm), Bcl-3 and methyl-CpG binding domain protein 1 (Mbd1) were downregulated in the lungs from Dmp1-null mice while Gas1 and Ect2 genes were upregulated. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
COL4A1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251917 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21931594 |
Egr-1 induced a time-dependent ECM gene expression program, with the number of ECM genes increasing >2.5-fold (from 16 to 41) between 24 and 48 h. Genes in this group include those coding for multiple collagens (COL4A1, COL4A2, COL11A1, COL7A1, COL10A1) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
ABCB1 |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253871 |
|
|
Homo sapiens |
Hematopoietic Cell |
| pmid |
sentence |
| 7565762 |
TPA induced EGR1 binding to the -69/+20 promoter sequences over a time course which correlated with increased MDR1 promoter activity and increased steady-state MDR1 RNA levels. These data suggest a role for EGR1 in modulating MDR1 promoter activity in hematopoietic cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
CYP2B6 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253874 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18303024 |
The CYP2B6 enzyme metabolizes commonly used therapeutics and also activates pro-drugs. The CAR directly binds to the distal enhancer element of the CYP2B6 promoter, which is essential in converging to its drug-sensing function onto promoter activity. However, this binding alone is not sufficient to activate the CYP2B6 promoter; the promoter requires EGR1 to enable CAR to activate the CYP2B6 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
COL11A1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251919 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21931594 |
Egr-1 induced a time-dependent ECM gene expression program, with the number of ECM genes increasing >2.5-fold (from 16 to 41) between 24 and 48 h. Genes in this group include those coding for multiple collagens (COL4A1, COL4A2, COL11A1, COL7A1, COL10A1) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
BCAR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253890 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 22431919 |
Overexpression or short interfering RNA (siRNA)-mediated down-regulation of EGR1 or NAB2, and chromatin immunoprecipitations indicated that EGR1 and NAB2 act in concert to positively regulate p130(Cas)/BCAR1 expression in breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
PTGES |
0.343 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254249 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21983014 |
In conclusion we demonstrated that treatment of HeLa cells with DMC leads to an enhanced formation of a complex consisting of NF-κB and HDAC1 that binds to the EGR1 promoter resulting in downregulation of EGR1 expression which plays a major role for transcriptional inhibition of mGPES-1 expression.|EGR1 downregulation seems to be the major effect of DMC leading to transcriptional inhibition of mPGES-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates quantity by expression
transcriptional regulation
|
EGR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263507 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11085989 |
We also show for the first time that leptin rapidly stimulates the mRNA expression of the zinc finger transcription factor, Egr-1, in the hypothalamus of mice. Our transfection results suggest that this regulation by leptin occurs by activation of theegr-1 promoter via activation of SHP-2 and of the ERK pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
FAP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254248 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20515787 |
Down-regulation of EGR1 resulted in a significant reduction in endogenous FAP mRNA expression. These findings identify the basal transcriptional requirements of FAP gene expression and show EGR1 is an important regulator of FAP expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
LHB |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254919 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19106114 |
EGR1 bound to two binding sites on the LHB promoter and this binding was increased by GNRH1. Mutation of either site or knockdown of endogenous EGR1 decreased basal and/or GNRH1-regulated promoter activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GNRH1 | up-regulates quantity by expression
transcriptional regulation
|
EGR1 |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254917 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19106114 |
GNRH1 induces expression of early growth response 1 (EGR1), which interacts with steroidogenic factor 1 (SF1) and paired-like homeodomain transcription factor 1 (PITX1) to regulate Lhb promoter activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NfKb-p65/p50 | down-regulates quantity by repression
transcriptional regulation
|
EGR1 |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254258 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21983014 |
In conclusion we demonstrated that treatment of HeLa cells with DMC leads to an enhanced formation of a complex consisting of NF-κB and HDAC1 that binds to the EGR1 promoter resulting in downregulation of EGR1 expression which plays a major role for transcriptional inhibition of mGPES-1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
SLC9A3 |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254269 |
|
|
Drosophila melanogaster |
SCHNEIDER-2 Cell |
| pmid |
sentence |
| 16464174 |
Transcriptional stimulation of the human NHE3 promoter activity by PMA: PKC independence and involvement of the transcription factor EGR-1|Co-transfection of Sp1 or Sp3 into SL2 cells activated the NHE3-reporter constructs, suggesting that Sp1 and Sp3 act as positive regulators of the NHE3 expression. In addition, overexpression of EGR-1 was sufficient to transactivate the NHE3-reporter gene activity |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
EGR1 | down-regulates quantity by repression
transcriptional regulation
|
HSD11B2 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253876 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15659537 |
Overexpression of p50 inhibited HSD11B2 promoter activity and overexpression of Egr-1 inhibited transactivation of the HSD11B2 promoter by p65/p50. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDAC1 | down-regulates quantity by repression
transcriptional regulation
|
EGR1 |
0.555 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254257 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21983014 |
In conclusion we demonstrated that treatment of HeLa cells with DMC leads to an enhanced formation of a complex consisting of NF-κB and HDAC1 that binds to the EGR1 promoter resulting in downregulation of EGR1 expression which plays a major role for transcriptional inhibition of mGPES-1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
SOD1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253897 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9867871 |
The human copper-zinc superoxide dismutase gene (SOD1) proximal promoter is regulated by Sp1, Egr-1, and WT1 via non-canonical binding sites. Egr-1 and two splicing variants of the Egr-related protein WT1 were able to transactivate the SOD1 promoter in co-transfection experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
PCSK2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253896 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9359835 |
we show that the transcription factor EGR-1 interacts with two distinct elements within the proximal human PC2 promoter region. Transfection experiments also demonstrate that EGR-1 is able to enhance PC2 promoter activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GAST | up-regulates quantity by expression
transcriptional regulation
|
EGR1 |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254252 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22228178 |
Gastrin inhibited proliferation of colon cancer cells by suppressing expression of EGR1 and AE2 and by blocking ERK phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Colon |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
GDF15 |
0.39 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254266 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 17715378 |
Isochaihulactone treatment increased the luciferase activity of NAG-1 in A549 cells transfected with the NAG-1 promoter construct. This induction increased expression of NAG-1 that was p53-independent and Sp1-dependent. Our findings suggest that NAG-1 expression is up-regulated by isochaihulactone through an ERK-dependent pathway involving the activation of EGR-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCAR1 | up-regulates quantity by expression
transcriptional regulation
|
EGR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253892 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 22431919 |
In MCF-7 cells, we identified a positive feedback loop where p130(Cas) positively regulates EGR1 and NAB2, which in turn induce p130(Cas) expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates activity
binding
|
PITX1 |
0.529 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254916 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19106114 |
GNRH1 induces expression of early growth response 1 (EGR1), which interacts with steroidogenic factor 1 (SF1) and paired-like homeodomain transcription factor 1 (PITX1) to regulate Lhb promoter activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
HYAL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253878 |
|
|
Homo sapiens |
253J Cell |
| pmid |
sentence |
| 18718911 |
In 253J-Lung and HT1376 bladder cancer cell lines, which show high HYAL-1 expression, transcription factors Egr-1, AP-2, and NFκB bind the HYAL-1 promoter. Because both SP1 and Egr-1 have two overlapping binding sites within the promoter (Fig. 5), it appears that although SP1 binding to the methylated HYAL-1 promoter turns off transcription, binding of Erg-1 (and also AP-2) to the unmethylated promoter turns on transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
EGR1
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