Summary

Name IRF8
Full Name Interferon regulatory factor 8
Synonyms IRF-8, Interferon consensus sequence-binding protein, H-ICSBP, ICSBP | ICSBP1
Primary ID Q02556
Links - -
Type protein
Relations 6
Function Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NCF2 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding IRF8 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CD68 0.08
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding IRF8 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding IRF8 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYBB 0.08
Publications: 1 Organism: Homo Sapiens