Summary

Name TRIM21
Full Name E3 ubiquitin-protein ligase TRIM21
Synonyms 52 kDa Ro protein, 52 kDa ribonucleoprotein autoantigen Ro/SS-A, RING finger protein 81, Ro(SS-A), Sjoegren syndrome type A antigen, SS-A, Tripartite motif-containing protein 21 | RNF81, RO52, SSA1
Primary ID P19474
Links - -
Type protein
Relations 10
Function E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139, PubMed:16297862, PubMed:16316627, PubMed:16472766, PubMed:16880511, PubMed:18022694, PubMed:18361920, PubMed:18641315, PubMed:18845142, PubMed:19675099). Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI (PubMed:26342464).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ TRIM21down-regulates activity img/direct_inhibition.png ubiquitination SQSTM1
Publications: 1 Organism: Homo Sapiens
+ TRIM21up-regulates quantity img/direct-activation.png monoubiquitination TRIM5 0.349
Publications: 1 Organism: Homo Sapiens
+ TRIM21down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination IRF7
Publications: 1 Organism: Homo Sapiens
+ TRIM21down-regulates quantity img/direct_inhibition.png ubiquitination DDX41
Publications: 1 Organism: Homo Sapiens
+ TRIM21down-regulates quantity img/direct_inhibition.png ubiquitination IRF8
Publications: 1 Organism: Homo Sapiens
+ TRIM21down-regulates quantity img/direct_inhibition.png ubiquitination SHMT2
Publications: 1 Organism: Homo Sapiens
+ GNAO1up-regulates activity img/direct-activation.png binding TRIM21 0.2
Publications: 1 Organism: Homo Sapiens
+ TRIM21down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination FASN 0.2
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination TRIM21 0.2
Publications: 1 Organism: Homo Sapiens
+ TRIM21down-regulates img/direct_inhibition.png ubiquitination GMPS 0.33
Publications: 1 Organism: Homo Sapiens