3.0
Summary
| Name |  IRF1View Modifications |
| Full Name | Interferon regulatory factor 1 |
| Synonyms | IRF-1 |
| Primary ID | P10914 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195, PubMed:32385160). Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195). Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:21389130, PubMed:22367195). Competes with the transcriptional repressor ZBED2 for binding to a common consensus sequence in gene promoters (PubMed:32385160). Its target genes for transcriptional activation activity include |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | IKBKE | down-regulates activity 
phosphorylation
|
IRF1 | 0.356 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | SP2 | up-regulates activity 
binding
|
IRF1 | 0.343 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MDM2 | down-regulates quantity
ubiquitination
|
IRF1 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | IRF1 | down-regulates quantity by repression
transcriptional regulation
|
DST | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | IRF1 | up-regulates activity
binding
|
IRF8 | 0.403 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | IRF1 | up-regulates quantity by expression 
transcriptional regulation
|
SOCS2 | 0.316 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | IRF1 | up-regulates quantity by expression
transcriptional regulation
|
SOCS1 | 0.389 |
| Publications: | 1 | Organism: | Homo Sapiens | |