Relation Results

Summary

Name MAP3K10
Full Name Mitogen-activated protein kinase kinase kinase 10
Synonyms Mixed lineage kinase 2, Protein kinase MST | MLK2, MST
Primary ID Q02779
Links - -
Type protein
Relations 8
Function Activates the JUN N-terminal pathway.

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Type: Score: Layout: SPV 
0.20.3620.3390.517MAP3K10TCF3SH3RF1NEUROD1MAPK8IP1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MAP3K10down-regulates img/direct_inhibition.png phosphorylation TCF3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-161523 Ser341 KALASIYsPDHSSNN Homo sapiens
pmid sentence
Mlk2 inhibits e47 transactivation activity on the trkb promote
Identifier Residue Sequence Organism Cell Line
SIGNOR-161527 Ser352 SSNNFSSsPSTPVGS Homo sapiens
pmid sentence
Mlk2 inhibits e47 transactivation activity on the trkb promote
Identifier Residue Sequence Organism Cell Line
SIGNOR-161531 Ser359 SPSTPVGsPQGLAGT Homo sapiens
pmid sentence
Mlk2 inhibits e47 transactivation activity on the trkb promote
Identifier Residue Sequence Organism Cell Line
SIGNOR-161540 Ser379 AGAPGALsPSYDGGL Homo sapiens
pmid sentence
Mlk2 inhibits e47 transactivation activity on the trkb promote
Identifier Residue Sequence Organism Cell Line
SIGNOR-161544 Thr355 NFSSSPStPVGSPQG Homo sapiens
pmid sentence
Mlk2 inhibits e47 transactivation activity on the trkb promote
Publications: 5 Organism: Homo Sapiens
+ SH3RF1up-regulates img/direct-activation.png binding MAP3K10 0.362
Identifier Residue Sequence Organism Cell Line
SIGNOR-97003 Homo sapiens Neuron
pmid sentence
Taken together, these findings support a model in which apoptotic stimuli or posh overexpression induce direct association between posh and inactive mlks.
Publications: 1 Organism: Homo Sapiens
+ MAP3K10up-regulates activity img/direct-activation.png binding NEUROD1 0.339
Identifier Residue Sequence Organism Cell Line
SIGNOR-234599 in vitro
pmid sentence
we identified two proteins that interact with ND, huntingtin-associated protein 1 (HAP1) and mixed-lineage kinase 2 (MLK2). Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2
Publications: 1 Organism: In Vitro
+ MAPK8IP1up-regulates img/direct-activation.png binding MAP3K10 0.517
Identifier Residue Sequence Organism Cell Line
SIGNOR-134552 Homo sapiens
pmid sentence
The c-jun nh2-terminal kinase (jnk)-interacting protein (jip) group of scaffold proteins (jip1, jip2, and jip3) can interact with components of the jnk signaling pathway and potently activate jnk.
Publications: 1 Organism: Homo Sapiens
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