3.0
Summary
| Name |  SH3RF1View Modifications |
| Full Name | E3 ubiquitin-protein ligase SH3RF1 |
| Synonyms | Plenty of SH3s, Protein POSH, RING finger protein 142, SH3 domain-containing RING finger protein 1, SH3 multiple domains protein 2 | KIAA1494, POSH, RNF142, SH3MD2 |
| Primary ID | Q7Z6J0 |
| Links |  -  -  |
| Type | protein |
| Relations | 15 |
| Pathways | SAPK/JNK Signaling |
| Function | Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT | down-regulates 
phosphorylation
|
SH3RF1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT2 | down-regulates
phosphorylation
|
SH3RF1 | 0.396 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 | down-regulates
phosphorylation
|
SH3RF1 | 0.401 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SH3RF1 | up-regulates activity 
ubiquitination
|
HERPUD1 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SH3RF1 | up-regulates
binding
|
MAPK8IP1 | 0.288 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | SAPK/JNK Signaling | |||
| + | SH3RF1 | up-regulates
binding
|
RAC2 | 0.265 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SH3RF1 | up-regulates
binding
|
MAP2K4 | 0.315 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | SAPK/JNK Signaling | |||
| + | SH3RF1 | up-regulates
binding
|
MAP3K12 | 0.383 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | SH3RF1 | up-regulates
binding
|
MAPK8 | 0.379 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | SAPK/JNK Signaling | |||
| + | SH3RF1 | up-regulates
binding
|
MAP3K11 | 0.515 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity
ubiquitination
|
SH3RF1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SH3RF1 | up-regulates
binding
|
MAP3K10 | 0.361 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SH3RF1 | up-regulates
binding
|
MAP2K7 | 0.336 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SH3RF1 | down-regulates quantity
ubiquitination
|
HGS | |
| Publications: | 1 | Organism: | Homo Sapiens | |