+ |
CSNK2A1 | down-regulates activity
phosphorylation
|
FKBP4 |
0.344 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-250865 |
Thr143 |
EFKGEDLtEEEDGGI |
in vitro |
|
pmid |
sentence |
9405642 |
Thr-143 in the hinge I region was identified as the major phosphorylation site for CK2. | Most importantly, CK2-phosphorylated FKBP52 did not bind to HSP90 |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
PTPN2 | down-regulates
dephosphorylation
|
FKBP4 |
0.4 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-97794 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
12552015 |
We have documented that a cellular protein that binds the immunosuppressant drug fk506, termed the fk506-binding protein (fkbp52), interacts with the single-stranded d sequence within the aav inverted terminal repeats, inhibits viral second-strand dna synthesis, and consequently limits high-efficiency transgene expression. Deliberate overexpression of the murine wild-type (wt) tc-ptp gene, but not that of a cysteine-to-serine (c-s) mutant, caused tyrosine dephosphorylation of fkbp52, leading to efficient viral second-strand dna synthesis and resulting in a significant increase in aav-mediated transduction efficiency in hela cells in vitro. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SRMS | down-regulates activity
phosphorylation
|
FKBP4 |
0.268 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-279764 |
|
|
Homo sapiens |
|
pmid |
sentence |
34077419 |
Together, these data indicate that SRMS inhibits the scaffolding function of its endogenous substrate FKBP51, thus antagonizing FKBP51-dependent inactivation of AKT (S4E Fig).|We demonstrate that SRMS phosphorylates FKBP51 to inhibit its scaffolding activity and promote its degradation through the ubiquitin-proteasome pathway. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FKBP4 | up-regulates activity
binding
|
AR |
0.719 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252034 |
|
|
Mus musculus |
Neuronal Cell Line |
pmid |
sentence |
19545546 |
We noted that FK506 altered nuclear localization of the GR and inhibited expression of GR-responsive genes. Furthermore, si-RNA knockdown of FKBP4 gene, coding for the immunophilin FKBP52, inhibited cortisol-activated GR nuclear translocation |
|
Publications: |
1 |
Organism: |
Mus Musculus |