| + |
SRMS | down-regulates activity
phosphorylation
|
MAP2K4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277903 |
Tyr269 |
RDAGCRPyMAPERID |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 37020040 |
SRMS directly phosphorylates MKK4 and inhibits MKK4-JNK-c-Jun activation upon platinum treatment. Platinum treatment-induced ROS activates SRMS, which inhibits MKK4 kinase activity by directly phosphorylating MKK4 at Y269 and Y307, and consequently attenuates MKK4-JNK activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277902 |
Tyr307 |
LATGRFPyPKWNSVF |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 37020040 |
SRMS directly phosphorylates MKK4 and inhibits MKK4-JNK-c-Jun activation upon platinum treatment. Platinum treatment-induced ROS activates SRMS, which inhibits MKK4 kinase activity by directly phosphorylating MKK4 at Y269 and Y307, and consequently attenuates MKK4-JNK activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SRMS | down-regulates quantity by destabilization
phosphorylation
|
FKBP5 |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277564 |
Tyr54 |
PMIGDKVyVHYKGKL |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 34077419 |
SRMS binds FKBP51 and phosphorylates tyrosine 54. Under nutrient-replete conditions, SRMS phosphorylates the PHLPP scaffold FK506-binding protein 51 (FKBP51), disrupts the FKBP51-PHLPP complex, and promotes FKBP51 degradation through the ubiquitin-proteasome pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRMS | down-regulates activity
phosphorylation
|
FKBP4 |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279764 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34077419 |
Together, these data indicate that SRMS inhibits the scaffolding function of its endogenous substrate FKBP51, thus antagonizing FKBP51-dependent inactivation of AKT (S4E Fig).|We demonstrate that SRMS phosphorylates FKBP51 to inhibit its scaffolding activity and promote its degradation through the ubiquitin-proteasome pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRMS |
phosphorylation
|
DOK1 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264569 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23822091 |
These data indicate that ectopically‐expressed GFP‐SRMS interacts with and mediates the phosphorylation of overexpressed GFP‐Dok1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |