| + |
CDK1 | down-regulates quantity 
phosphorylation
|
CREM |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276346 |
Ser271 |
QGVVMAAsPGSLHSP |
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 21767532 |
In this report data is presented demonstrating that ICER is phosphorylated by the mitotic kinase cdk1. Phosphorylation of ICER on a discrete residue targeted ICER to be monoubiquitinated. Different from unphosphorylated, phosphorylated and polyubiquitinated ICER, monoubiquitinated ICER was found to be cytosolic. Taken together, these results hinted on a mechanism for the observed abnormal subcellular localization of ICER in human prostate tumors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | down-regulates quantity by destabilization
phosphorylation
|
CREM |
0.419 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275978 |
Ser277 |
ASPGSLHsPQQLAEE |
Mus musculus |
AtT-20 Cell |
| pmid |
sentence |
| 11466319 |
The MAPKs extracellular signal-regulated kinases 1 and 2 physically interact with ICER and mediated the phosphorylation of ICER on a critical serine residue (Ser-41). A mutant form of ICER in which Ser-41 was substituted by alanine had a half-life 4-5 h longer than its wild-type counterpart. This alteration in stability was due to the inability of the Ser-41-mutant ICER to be efficiently ubiquitinated and degraded via the ubiquitin-proteasome pathway. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CDK1 | down-regulates quantity by destabilization
phosphorylation
|
CREM |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275979 |
Ser277 |
ASPGSLHsPQQLAEE |
Mus musculus |
AtT-20 Cell |
| pmid |
sentence |
| 11466319 |
The MAPKs extracellular signal-regulated kinases 1 and 2 physically interact with ICER and mediated the phosphorylation of ICER on a critical serine residue (Ser-41). A mutant form of ICER in which Ser-41 was substituted by alanine had a half-life 4-5 h longer than its wild-type counterpart. This alteration in stability was due to the inability of the Ser-41-mutant ICER to be efficiently ubiquitinated and degraded via the ubiquitin-proteasome pathway. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FHL5 | up-regulates activity 
binding
|
CREM |
0.651 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-222111 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10086359 |
ACT (for activator of CREM in testis), a LIM-only protein which specifically associates with CREM. ACT is expressed coordinately with CREM in a tissue- and developmentally regulated manner. It strongly stimulates CREM transcriptional activity in yeast and mammalian cells and contains an intrinsic activation function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREM | down-regulates quantity by repression
transcriptional regulation
|
IL2 |
0.495 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261576 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 12626549 |
In this study we show that CREM is transcriptionally induced in T cells following stimulation through CD3 and CD28, binds to the IL-2 promoter in vivo, and suppresses IL-2 production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CREM
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- 