4.0
Summary
| Name |  EIF4G1View Modifications |
| Full Name | Eukaryotic translation initiation factor 4 gamma 1 |
| Synonyms | eIF-4-gamma 1, eIF-4G 1, eIF-4G1, p220 | EIF4F, EIF4G, EIF4GI |
| Primary ID | Q04637 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Inhibitors | 4E2RCat |
| Function | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCA | up-regulates activity 
phosphorylation
|
EIF4G1 | 0.258 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 4E2RCat | down-regulates activity 
chemical inhibition
|
EIF4G1 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EIF3_complex | up-regulates activity
stabilization
|
EIF4G1 | 0.642 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EIF4G1 | form complex 
binding
|
eIF4F_complex | 0.928 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Kidney | |||