+ |
EIF3_complex | up-regulates activity
stabilization
|
EIF4G1 |
0.624 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269155 |
|
|
Homo sapiens |
|
pmid |
sentence |
17581632 |
EIF3 plays many functions in initiation complex formation. It interacts with eIF1, eIF5, eIF4B and eIF4G, and the direct interaction between eIF3 and eIF4G may serve as a bridge between the 40S ribosomal subunit and eIF4F-bound mRNA (Hershey and Merrick, 2000). eIF3 stabilizes the binding of the eIF2-GTP-Met-tRNAiMet ternary complex to the 40S subunit |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
4E2RCat | down-regulates activity
chemical inhibition
|
EIF4G1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260188 |
|
|
Homo sapiens |
Epithelial Cell |
pmid |
sentence |
21507972 |
Characterization of 4E2RCat, an inhibitor of eIF4E-eIF4G interaction. Herein we describe a molecule from this screen that prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. This inhibitor significantly decreased human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
EIF4G1 | form complex
binding
|
eIF4F_complex |
0.926 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-108518 |
|
|
Homo sapiens |
|
pmid |
sentence |
11408474 |
Eif4a interacts with a scaffold protein, eif4g, to form complexes that also contain the cap-binding protein eif4e, which binds the cap structure (m7gpppn_) at the 5_-end of the mrna. These complexes are termed eif4f. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
Kidney |