Relation Results

Summary

Name EIF4G1
Full Name Eukaryotic translation initiation factor 4 gamma 1
Synonyms eIF-4-gamma 1, eIF-4G 1, eIF-4G1, p220 | EIF4F, EIF4G, EIF4GI
Primary ID Q04637
Links - -
Type protein
Relations 4
Inhibitors 4E2RCat
Function Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structu ...
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Type: Score: Layout: SPV 
0.2590.80.6360.927PRKCAEIF4G14E2RCatEIF3_complexeIF4F_complex

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCAup-regulates activity img/direct-activation.png phosphorylation EIF4G1 0.259
Identifier Residue Sequence Organism Cell Line
SIGNOR-276327 Ser1185 RTPATKRsFSKEVEE Homo sapiens HEK-293 Cell
pmid sentence
Phospho-proteomic and mutational analyses revealed that eIF4G1 is a substrate for PKCα at Ser1186. 
Publications: 1 Organism: Homo Sapiens
+ 4E2RCatdown-regulates activity img/direct_inhibition.png chemical inhibition EIF4G1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-260188 Homo sapiens Epithelial Cell
pmid sentence
Characterization of 4E2RCat, an inhibitor of eIF4E-eIF4G interaction. Herein we describe a molecule from this screen that prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. This inhibitor significantly decreased human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers.
Publications: 1 Organism: Homo Sapiens
+ EIF3_complexup-regulates activity img/direct-activation.png stabilization EIF4G1 0.636
Identifier Residue Sequence Organism Cell Line
SIGNOR-269155 Homo sapiens
pmid sentence
EIF3 plays many functions in initiation complex formation. It interacts with eIF1, eIF5, eIF4B and eIF4G, and the direct interaction between eIF3 and eIF4G may serve as a bridge between the 40S ribosomal subunit and eIF4F-bound mRNA (Hershey and Merrick, 2000). eIF3 stabilizes the binding of the eIF2-GTP-Met-tRNAiMet ternary complex to the 40S subunit
Publications: 1 Organism: Homo Sapiens
+ EIF4G1form complex img/form-complex.png binding eIF4F_complex 0.927
Identifier Residue Sequence Organism Cell Line
SIGNOR-108518 Homo sapiens
pmid sentence
Eif4a interacts with a scaffold protein, eif4g, to form complexes that also contain the cap-binding protein eif4e, which binds the cap structure (m7gpppn_) at the 5_-end of the mrna. These complexes are termed eif4f.
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
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