Summary

Name TLE1
Full Name Transducin-like enhancer protein 1
Synonyms E(Sp1) homolog, Enhancer of split groucho-like protein 1, ESG1
Primary ID Q04724
Links - -
Type protein
Relations 6
Function Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation TLE1 0.329
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SIX6 0.406
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding LEF1 0.673
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding SIX3 0.41
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding TLE1 0.2
Publications: 1 Organism: Homo Sapiens