3.0
Summary
| Name |  TLE1View Modifications |
| Full Name | Transducin-like enhancer protein 1 |
| Synonyms | E(Sp1) homolog, Enhancer of split groucho-like protein 1, ESG1 |
| Primary ID | Q04724 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | up-regulates 
phosphorylation
|
TLE1 | 0.326 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | TLE1 | up-regulates activity
binding
|
SIX6 | 0.404 |
| Publications: | 1 | Organism: | In Vitro | |
| + | TLE1 | down-regulates activity 
binding
|
LEF1 | 0.676 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PHF12 | up-regulates activity
binding
|
TLE1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TLE1 | up-regulates activity
binding
|
SIX3 | 0.409 |
| Publications: | 1 | Organism: | In Vitro | |