| + |
PHF12 | up-regulates activity 
binding
|
TLE3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266993 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11390640 |
We have cloned and characterized a new member of the PHD zinc finger family called Pf1 that interacts with two global transcription corepressors: mSin3A and TLE. Pf1 interacts with TLE. The Groucho/TLE proteins are members of an abundant corepressor family, and we hypothesized that Pf1 might interact with TLE family members. Together, these data suggest that in the absence of interactions with mSin3A, Gal4-Pf1 (102–273 L212P/A216P)-dependent repression can be attributed to interaction with endogenous TLE. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHF12 | up-regulates activity
binding
|
TLE4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266989 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11390640 |
We have cloned and characterized a new member of the PHD zinc finger family called Pf1 that interacts with two global transcription corepressors: mSin3A and TLE. Pf1 interacts with TLE. The Groucho/TLE proteins are members of an abundant corepressor family, and we hypothesized that Pf1 might interact with TLE family members. Together, these data suggest that in the absence of interactions with mSin3A, Gal4-Pf1 (102–273 L212P/A216P)-dependent repression can be attributed to interaction with endogenous TLE. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHF12 | up-regulates activity
binding
|
TLE1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266994 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11390640 |
We have cloned and characterized a new member of the PHD zinc finger family called Pf1 that interacts with two global transcription corepressors: mSin3A and TLE. Pf1 interacts with TLE. The Groucho/TLE proteins are members of an abundant corepressor family, and we hypothesized that Pf1 might interact with TLE family members. Together, these data suggest that in the absence of interactions with mSin3A, Gal4-Pf1 (102–273 L212P/A216P)-dependent repression can be attributed to interaction with endogenous TLE. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHF12 | up-regulates activity
binding
|
SIN3A |
0.787 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266995 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11390640 |
Pf1 interacts with mSin3A in vivo. Gal4-Pf1 repressed activity of the reporter gene fivefold relative to Gal4 alone (Fig. (Fig.5A),5A), suggesting that DNA-bound Pf1 was capable of recruiting functional mSin3A complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHF12 | form complex 
binding
|
Sin3B_complex |
0.791 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266969 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21041482 |
We report here the identification of a mammalian complex containing the corepressor Sin3B, the histone deacetylase HDAC1, Mrg15, and the PHD finger-containing Pf1 and show that this complex plays important roles in regulation of transcription. Sin3B, Pf1, Mrg15, and HDAC1 associate within a stable complex that binds H3K4me3/H3K36me3-enriched nucleosomes. We identify mammalian Pf1, a PHD finger protein, as a homologue of Rco1, and show that all four components, Sin3B, HDAC1, Mrg15, and Pf1, can form a stable complex, which is recruited downstream of the transcriptional start site through complex interactions with histones. these results indicate that the Pf1/Sin3B-containing complex is recruited at discrete sites within actively transcribed loci, likely through its interaction with H3K4me3/H3K36me3-enriched chromatin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHF12 | up-regulates activity
binding
|
TLE5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266990 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11390640 |
We have cloned and characterized a new member of the PHD zinc finger family called Pf1 that interacts with two global transcription corepressors: mSin3A and TLE. Pf1 interacts with TLE. The Groucho/TLE proteins are members of an abundant corepressor family, and we hypothesized that Pf1 might interact with TLE family members. Together, these data suggest that in the absence of interactions with mSin3A, Gal4-Pf1 (102–273 L212P/A216P)-dependent repression can be attributed to interaction with endogenous TLE. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHF12 | up-regulates activity
binding
|
TLE6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266991 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11390640 |
We have cloned and characterized a new member of the PHD zinc finger family called Pf1 that interacts with two global transcription corepressors: mSin3A and TLE. Pf1 interacts with TLE. The Groucho/TLE proteins are members of an abundant corepressor family, and we hypothesized that Pf1 might interact with TLE family members. Together, these data suggest that in the absence of interactions with mSin3A, Gal4-Pf1 (102–273 L212P/A216P)-dependent repression can be attributed to interaction with endogenous TLE. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHF12 | up-regulates activity
binding
|
TLE2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266992 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11390640 |
We have cloned and characterized a new member of the PHD zinc finger family called Pf1 that interacts with two global transcription corepressors: mSin3A and TLE. Pf1 interacts with TLE. The Groucho/TLE proteins are members of an abundant corepressor family, and we hypothesized that Pf1 might interact with TLE family members. Together, these data suggest that in the absence of interactions with mSin3A, Gal4-Pf1 (102–273 L212P/A216P)-dependent repression can be attributed to interaction with endogenous TLE. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PHF12
- 
- 