+ |
PHF12 | up-regulates activity
binding
|
TLE3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266993 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
11390640 |
We have cloned and characterized a new member of the PHD zinc finger family called Pf1 that interacts with two global transcription corepressors: mSin3A and TLE. Pf1 interacts with TLE. The Groucho/TLE proteins are members of an abundant corepressor family, and we hypothesized that Pf1 might interact with TLE family members. Together, these data suggest that in the absence of interactions with mSin3A, Gal4-Pf1 (102–273 L212P/A216P)-dependent repression can be attributed to interaction with endogenous TLE. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
XIAP | up-regulates activity
ubiquitination
|
TLE3 |
0.493 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278528 |
|
|
Homo sapiens |
|
pmid |
sentence |
22304967 |
These findings suggest that TLE3 ubiquitylation by XIAP may be required during Wnt pathway activation to facilitate its dissociation from TCF/Lef, allowing subsequent beta-catenin binding and transcriptional activation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |