| + |
MAPK8 | down-regulates quantity by destabilization 
phosphorylation
|
EEF1A2 |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276491 |
Ser205 |
GDNMLEPsPNMPWFK |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 23608534 |
Ribosome-associated JNK phosphorylates the eukaryotic translation elongation factor 1A isoform 2 (eEF1A2) on serines 205 and 358 to promote degradation of NSPs by the proteasome. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276492 |
Ser358 |
GQISAGYsPVIDCHT |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 23608534 |
Ribosome-associated JNK phosphorylates the eukaryotic translation elongation factor 1A isoform 2 (eEF1A2) on serines 205 and 358 to promote degradation of NSPs by the proteasome. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
BRAF | down-regulates quantity by destabilization
phosphorylation
|
EEF1A2 |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276406 |
Ser21 |
GHVDSGKsTTTGHLI |
in vitro |
|
| pmid |
sentence |
| 22378069 |
Mass spectrometry identified in vitro S21 and T88 as phosphorylation sites mediated by B-Raf but not C-Raf on eEF1A1 whereas S21 was phosphorylated on eEF1A2 by both B- and C-Raf. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RAF1 | down-regulates quantity by destabilization
phosphorylation
|
EEF1A2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276407 |
Ser21 |
GHVDSGKsTTTGHLI |
in vitro |
|
| pmid |
sentence |
| 22378069 |
Mass spectrometry identified in vitro S21 and T88 as phosphorylation sites mediated by B-Raf but not C-Raf on eEF1A1 whereas S21 was phosphorylated on eEF1A2 by both B- and C-Raf. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PRKCB | up-regulates activity 
phosphorylation
|
EEF1A2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263166 |
Ser53 |
AAEMGKGsFKYAWVL |
Mus musculus |
|
| pmid |
sentence |
| 20923971 |
PKCβI phosphorylates eEF1A at Ser53.our proteomics exploration of cPKC signaling in the nuclei of C2C12 cells demonstrated that the up-regulation of eEF1A intranuclear content, evoked by insulin, is associated with an increase in the phosphorylation of the Ser53 residue of the protein. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EEF1A2 | up-regulates
relocalization
|
Asn-tRNA(Asn) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269526 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1B complex | up-regulates activity
guanine nucleotide exchange factor
|
EEF1A2 |
0.715 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269388 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. An inactive eEF1A-GDP moiety leaves the ribosome and must be recycled to eEF1A-GTP before binding another aa-tRNA. This GTP exchange process is the function of the nucleotide exchange factor eEF1B complex, which exchanges GDP for GTP to regenerate active eEF1A. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates 
|
Translational_elongation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269394 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Met-tRNA(Met) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269524 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Gly-tRNA(Gly) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269541 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
His-tRNA(His) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269531 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Gln-tRNA(Gln) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269530 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Tyr-tRNA(Tyr) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269538 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Ser-tRNA(Ser) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269535 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Lys-tRNA(Lys) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269522 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Phe-tRNA(Phe) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269540 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Arg-tRNA(Arg) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269525 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Glu-tRNA(Glu) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269529 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Cys-tRNA(Cys) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269528 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Ile-tRNA(Ile) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269532 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Thr-tRNA(Thr) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269536 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Ala-tRNA(Ala) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269523 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
N | down-regulates activity
binding
|
EEF1A2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260260 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18448518 |
The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Asp-tRNA(Asp) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269527 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Pro-tRNA(Pro) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269534 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Val-tRNA(Val) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269539 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Trp-tRNA(Trp) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269537 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EEF1A2 | up-regulates
relocalization
|
Leu-tRNA(Leu) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269533 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23699257 |
During protein synthesis, eEF1A binds to and delivers aminoacylated tRNAs (aa-tRNAs) to the elongating ribosome (Fig. 1). GTP bound to eEF1A is hydrolyzed upon codon-anticodon match between an aa-tRNA in the A site of the ribosome and mRNA bound to the ribosome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
EEF1A2
- 
- 