| + |
EGR3 | up-regulates quantity by expression 
transcriptional regulation
|
NAB2 |
0.5 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253882 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20506119 |
In melanoma and carcinoma cells EGR1 activates NAB2 expression. we investigated the influence of EGR2 and EGR3 on NAB2 expression in melanoma and carcinoma cells. Here, we show that like EGR1, EGR2 and EGR3 induced NAB2 expression in these cells. EGR1 and EGR3 act in concert on the NAB2 promoter and are more potent activators of NAB2 transcription than EGR2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR3 | down-regulates quantity by repression 
transcriptional regulation
|
NAB2 |
0.5 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253884 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 20506119 |
In T lymphocytes EGR2 and EGR3 have been shown to inhibit NAB2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAB2 | down-regulates quantity by repression
transcriptional regulation
|
EGR3 |
0.5 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253887 |
|
|
Homo sapiens |
Epithelial Cell |
| pmid |
sentence |
| 20506119 |
Our results suggest that in many cells of neuroectodermal and epithelial origin EGR1, EGR2, and EGR3 activate NAB2 transcription which is in turn repressed by NAB2, thus establishing a negative feedback loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
EGR3
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- 