| + |
NAB2 | down-regulates quantity by repression 
transcriptional regulation
|
TNFSF10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253893 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22128144 |
In the present study, we investigated the molecular basis for the differential regulation of TRAIL in helped versus helpless CD8(+) T cells by comparing their transcriptional profiles, and have identified a transcriptional corepressor, NGFI-A binding protein 2 (Nab2), that is selectively induced in helped CD8(+) T cells. Enforced expression of Nab2 prevents TRAIL induction after restimulation of primary helpless CD8(+) T cells, and expression of a dominant-negative form of Nab2 in helped CD8(+) T cells impairs their secondary proliferative response that is reversible by TRAIL blockade. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCAR1 | up-regulates quantity by expression 
transcriptional regulation
|
NAB2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253891 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 22431919 |
In MCF-7 cells, we identified a positive feedback loop where p130(Cas) positively regulates EGR1 and NAB2, which in turn induce p130(Cas) expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL2 | up-regulates quantity by expression
transcriptional regulation
|
NAB2 |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253894 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22128144 |
We observe that the CD8(+) T-cell autocrine growth factor IL-2 coordinately increases Nab2 expression and decreases TRAIL expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAB2 | down-regulates quantity by repression
transcriptional regulation
|
GFI1 |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256042 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16923394 |
Impairing Egr-2 or Nab-2 induction resulted in sustained expression of Gfi-1, demonstrating that Egr-2 and Nab-2 negatively regulate Gfi-1 expression . Importantly, the Gfi-1 promoter was repressed via the Egr site by coexpression of Egr-2 and Nab-2. Thus, Egr-2 and Nab-2 directly repress the Gfi-1 gene. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
EGR3 | up-regulates quantity by expression
transcriptional regulation
|
NAB2 |
0.501 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253882 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20506119 |
In melanoma and carcinoma cells EGR1 activates NAB2 expression. we investigated the influence of EGR2 and EGR3 on NAB2 expression in melanoma and carcinoma cells. Here, we show that like EGR1, EGR2 and EGR3 induced NAB2 expression in these cells. EGR1 and EGR3 act in concert on the NAB2 promoter and are more potent activators of NAB2 transcription than EGR2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
NAB2 |
0.612 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253881 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20506119 |
In melanoma and carcinoma cells EGR1 activates NAB2 expression. we investigated the influence of EGR2 and EGR3 on NAB2 expression in melanoma and carcinoma cells. Here, we show that like EGR1, EGR2 and EGR3 induced NAB2 expression in these cells. EGR1 and EGR3 act in concert on the NAB2 promoter and are more potent activators of NAB2 transcription than EGR2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAB2 | up-regulates quantity by expression
transcriptional regulation
|
BCAR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253889 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 22431919 |
Overexpression or short interfering RNA (siRNA)-mediated down-regulation of EGR1 or NAB2, and chromatin immunoprecipitations indicated that EGR1 and NAB2 act in concert to positively regulate p130(Cas)/BCAR1 expression in breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR2 | down-regulates quantity by repression
transcriptional regulation
|
NAB2 |
0.594 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253885 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 20506119 |
In T lymphocytes EGR2 and EGR3 have been shown to inhibit NAB2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
EGR3 | down-regulates quantity by repression
transcriptional regulation
|
NAB2 |
0.501 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253884 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 20506119 |
In T lymphocytes EGR2 and EGR3 have been shown to inhibit NAB2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR2 | up-regulates quantity by expression
transcriptional regulation
|
NAB2 |
0.594 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253883 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20506119 |
In melanoma and carcinoma cells EGR1 activates NAB2 expression. we investigated the influence of EGR2 and EGR3 on NAB2 expression in melanoma and carcinoma cells. Here, we show that like EGR1, EGR2 and EGR3 induced NAB2 expression in these cells. EGR1 and EGR3 act in concert on the NAB2 promoter and are more potent activators of NAB2 transcription than EGR2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
NAB2 | down-regulates quantity by repression
transcriptional regulation
|
EGR2 |
0.594 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253888 |
|
|
Homo sapiens |
Epithelial Cell |
| pmid |
sentence |
| 20506119 |
Our results suggest that in many cells of neuroectodermal and epithelial origin EGR1, EGR2, and EGR3 activate NAB2 transcription which is in turn repressed by NAB2, thus establishing a negative feedback loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
NAB2 | down-regulates quantity by repression
transcriptional regulation
|
EGR3 |
0.501 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253887 |
|
|
Homo sapiens |
Epithelial Cell |
| pmid |
sentence |
| 20506119 |
Our results suggest that in many cells of neuroectodermal and epithelial origin EGR1, EGR2, and EGR3 activate NAB2 transcription which is in turn repressed by NAB2, thus establishing a negative feedback loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAB2 | down-regulates quantity by repression
transcriptional regulation
|
EGR1 |
0.612 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253886 |
|
|
Homo sapiens |
Epithelial Cell |
| pmid |
sentence |
| 20506119 |
Our results suggest that in many cells of neuroectodermal and epithelial origin EGR1, EGR2, and EGR3 activate NAB2 transcription which is in turn repressed by NAB2, thus establishing a negative feedback loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPI1 | up-regulates quantity by expression
transcriptional regulation
|
NAB2 |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256039 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16923394 |
PU.1 Induces Egr-2 and Nab-2, which Repress Neutrophil Genes during Macrophage Differentiation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
3.0
NAB2
- 
- 