Relation Results

Summary

Name TJP1
Full Name Tight junction protein ZO-1
Synonyms Tight junction protein 1, Zona occludens protein 1, Zonula occludens protein 1 | ZO1
Primary ID Q07157
Links - -
Type protein
Relations 2
Function TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesi ...
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Type: Score: Layout: SPV 
0.20.456TJP1NHSARVCF

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Relations
Regulator
Mechanism
target
score ℹ
+ TJP1up-regulates activity img/direct-activation.png binding NHS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253567 Mus musculus
pmid sentence
NHS-A is a novel interactor of ZO-1 and is expected to have a role at tight junctions. Its recruitment to these junctions is dependent upon their assembly.
Publications: 1 Organism: Mus Musculus
+ TJP1up-regulates activity img/direct-activation.png binding ARVCF 0.456
Identifier Residue Sequence Organism Cell Line
SIGNOR-252121 Canis lupus familiaris MDCK Cell
pmid sentence
We identified ARVCF as a binding partner of ZO-1 and ZO-2 and characterized the role of PDZ-domain proteins in plasma membrane and nuclear localization of ARVCF. E-cadherin, ZO-1, and ARVCF are recruited to sites of initial cell-cell contact. Binding of the ZO-1 PDZ domains per se does not facilitate membrane recruitment of ARVCF, indicating a requirement for the intact ZO-1 and possibly its association with membrane proteins and/or the cytoskeleton for this process.
Publications: 1 Organism: Canis Lupus Familiaris
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